Biologically Active Quinolinone Alkaloid from the Marine Fungus Penicillium polonicum KMM 4719

IF 1 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Applied Biochemistry and Microbiology Pub Date : 2025-04-07 DOI:10.1134/S0003683824605912

S. S. Starnovskaya, N. N. Kirichuk, V. E. Chausova, U. V. Khudyakova, E. A. Chingizova, A. R. Chingizov, A. N. Yurchenko, E. A. Yurchenko

引用次数: 0

Abstract

The marine fungal strain KMM 4719 was isolated from the sea cucumber Apostichopus japonicus and identified as Penicillium polonicum based on three molecular genetic markers: ITS, BenA, and CaM. 3-O-methylviridicatin was isolated from the ethyl acetate extract of the strain culture. 3-O-methylviridicatin has demonstrated cardioprotective activity for the first time, as well as urease inhibitory activity (IC₅₀ 97.3 μM). In addition, 3-O-methylviridicatin at a concentration of 100 μM (25.1 μg/mL) inhibited the growth of the yeast-like fungus Candida albicans at 23.2%.

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来源期刊

Applied Biochemistry and Microbiology 生物-生物工程与应用微生物

CiteScore

1.70

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.