Thermoresponsive [(PLA)-co-(Car)] based frustum-shaped capsules with extended porosity for biosensing and biomedical applications

IF 2.5 4区材料科学 Q2 CHEMISTRY, APPLIED

Journal of Porous Materials Pub Date : 2024-11-20 DOI:10.1007/s10934-024-01681-x

Chander Amgoth Pawar, David Xu Luo, Divya Rokkala, Raju Bura, Gundeti Bhagyalaxmi, Rampilla Sudha Rani, Krishna Veni Mannam, Kothamasu Suresh Babu

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引用次数: 0

Abstract

We present, a facile method for the synthesis of block co-polymer (BCP) of [(PLA)-b-(Car)], (PLA-Poly Lactic acid and Car-Carbazole). BCP results in the design and development of cone and ice-cream cup-shaped frustums with nanoscale porosity for bio-sensing and drug delivery applications. [(PLA)-b-(Car)] was conjugated through condensation polymerization between amine proton and hydroxyl groups of PLA and Car. Thermoplastic PLA is responsible for desired size, shape, and porosity over the surface. The size, shape, and morphology of the [(PLA)-b-(Car)] are tunable based on suitable solvents and thermal treatment. Interestingly, design of nanoporous hollow (half-broken coconut type) capsules has been carried out without using any precursors and surfactants. Synthesis of [(PLA)-b-(Car)] has been confirmed through the Fourier transform infrared (FTIR), nuclear magnetic resonance (¹H NMR). However, the morphology and surface properties of capsules were confirmed through field emission scanning electron microscopy (FE-SEM), Bruner Emmett Teller (BET), and atomic force microscopy (AFM) characterizations. The capsule size ranges from ~ 200 nm to 1 μm (in diameter) and porosity scales from ~ 60 to 80 nm. The hollow and porous surface of the capsules with biosensing and drug delivery applications can be considered as a unique and novel characteristic property of our invention. This kind of novel cone and ice cream cup-shaped hollow frustums can be used as a stimuli-responsive catalytic activity through the fluorescence measurement of cysteine and gold nanoparticle [(Cys)-(Au⁺)] for enhanced payload and biomedical applications.

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热响应[(PLA)-co-(Car)]基锥状胶囊，具有扩展孔隙度，用于生物传感和生物医学应用

我们介绍了一种合成[(PLA)-b-(Car)]嵌段共聚物（BCP）（PLA-聚乳酸和 Car-咔唑）的简便方法。BCP 可设计和开发具有纳米级孔隙率的锥形和雪糕杯形凹凸体，用于生物传感和药物输送。(聚乳酸)-b-(Car)]是通过聚乳酸的胺质子和羟基与 Car 的缩合聚合而成的。热塑性聚乳酸可在表面形成所需的尺寸、形状和孔隙率。通过适当的溶剂和热处理，[(PLA)-b-(Car)]的大小、形状和形态均可调整。有趣的是，在不使用任何前体和表面活性剂的情况下，也能设计出纳米多孔空心（半破椰子型）胶囊。傅立叶变换红外光谱（FTIR）和核磁共振（1H NMR）证实了[(PLA)-b-(Car)]的合成。然而，胶囊的形态和表面特性则是通过场发射扫描电子显微镜（FE-SEM）、布鲁纳-艾美特-泰勒（BET）和原子力显微镜（AFM）进行表征的。胶囊的尺寸范围为 ~ 200 nm 至 1 μm（直径），孔隙率范围为 ~ 60 至 80 nm。具有生物传感和药物输送应用的空心多孔胶囊表面可被视为本发明独特而新颖的特征特性。通过对半胱氨酸和金纳米粒子[(Cys)-(Au+)]的荧光测量，这种新颖的锥形和冰淇淋杯形中空胶囊可用作刺激响应催化活性，以增强有效载荷和生物医学应用。

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来源期刊

Journal of Porous Materials 工程技术-材料科学：综合

CiteScore

4.80

自引率

7.70%

发文量

203

审稿时长

2.6 months

期刊介绍： The Journal of Porous Materials is an interdisciplinary and international periodical devoted to all types of porous materials. Its aim is the rapid publication of high quality, peer-reviewed papers focused on the synthesis, processing, characterization and property evaluation of all porous materials. The objective is to establish a unique journal that will serve as a principal means of communication for the growing interdisciplinary field of porous materials. Porous materials include microporous materials with 50 nm pores. Examples of microporous materials are natural and synthetic molecular sieves, cationic and anionic clays, pillared clays, tobermorites, pillared Zr and Ti phosphates, spherosilicates, carbons, porous polymers, xerogels, etc. Mesoporous materials include synthetic molecular sieves, xerogels, aerogels, glasses, glass ceramics, porous polymers, etc.; while macroporous materials include ceramics, glass ceramics, porous polymers, aerogels, cement, etc. The porous materials can be crystalline, semicrystalline or noncrystalline, or combinations thereof. They can also be either organic, inorganic, or their composites. The overall objective of the journal is the establishment of one main forum covering the basic and applied aspects of all porous materials.