Harnessing killer yeast system: from molecular insight to real world biocontrol solution

IF 2.3 3区生物学 Q3 MICROBIOLOGY

Archives of Microbiology Pub Date : 2025-04-08 DOI:10.1007/s00203-025-04318-y

Prabhsangam Kaur Dhillon, Manpreet Kaur, Sukesh Chander Sharma, Akhtar Mahmood

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引用次数: 0

Abstract

The biocontrol mechanisms of yeasts are gaining global attention as a vital response to the rising threat of antimicrobial resistance in emerging pathogens. With their diverse genetic traits, yeasts present potent antagonistic capabilities that have extensive applications across various sectors. This review examines the fundamental mechanisms and molecular bases of yeast antagonism, emphasizing innovative screening techniques for identifying effective strains. Key molecular methods, including gene identification, sequence analysis, and expression studies, reveal insights into their modes of action, such as nutrient competition, mycocin production, and volatile organic compound release. While the potential of antagonistic yeasts spans crop protection, food safety, and disease prevention, their commercial availability remains limited. To foster adoption, there is an urgent need for advanced screening methods and deeper molecular understanding. Future research should prioritize the optimization and commercialization of yeast-based biocontrol products, effectively bridging the gap between scientific discovery and practical application in combating harmful pathogens.

Graphical abstract

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利用杀手酵母系统：从分子洞察到现实世界的生物控制解决方案

酵母的生物防治机制作为应对新出现病原体耐药性威胁的重要手段，正受到全球关注。酵母具有多种遗传特性，具有强大的拮抗能力，在各个领域都有广泛的应用。本文综述了酵母拮抗的基本机制和分子基础，重点介绍了鉴定有效菌株的创新筛选技术。关键的分子方法，包括基因鉴定、序列分析和表达研究，揭示了它们的作用模式，如营养竞争、霉菌素生产和挥发性有机化合物释放。虽然拮抗酵母的潜力跨越作物保护、食品安全和疾病预防，但它们的商业可用性仍然有限。为了促进收养，迫切需要先进的筛选方法和更深入的分子理解。未来的研究应优先考虑以酵母为基础的生物防治产品的优化和商业化，有效地弥合科学发现与实际应用之间的差距，以对抗有害病原体。图形抽象

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来源期刊

Archives of Microbiology 生物-微生物学

CiteScore

4.90

自引率

3.60%

发文量

601

审稿时长

3 months

期刊介绍： Research papers must make a significant and original contribution to microbiology and be of interest to a broad readership. The results of any experimental approach that meets these objectives are welcome, particularly biochemical, molecular genetic, physiological, and/or physical investigations into microbial cells and their interactions with their environments, including their eukaryotic hosts. Mini-reviews in areas of special topical interest and papers on medical microbiology, ecology and systematics, including description of novel taxa, are also published. Theoretical papers and those that report on the analysis or ''mining'' of data are acceptable in principle if new information, interpretations, or hypotheses emerge.