A Bioavailable Nanocomposition of Chitosan–Copper Nanoparticles as an Alternative to Antibiotics in Broiler Feed

IF 1 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
K. V. Apryatina, I. A. Egorov, S. D. Zaitsev, G. Yu. Laptev, E. V. Salomatina, L. A. Smirnova, A. G. Samodelkin, V. G. Frolov
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Abstract

Pathogens pose a serious threat to agriculture as they cause diseases, reduce the growth rate and efficiency of farm birds and animals and causing economic losses. Therefore, antibiotics continue to be used to combat pathogens and for prevention, despite all their negative effects and the bacterial resistance to them. Effective alternatives are needed that exclude the use of vaccines and drugs. An aggregatively stable nanocomposition of chitosan and nanoparticles of copper with an average size of the latter of 25–30 nm was developed. The bactericidal effect of the nanocomposition was shown in vitro on the pathogenic bacteria Enterococcus faecalis and investigated in vivo in the composition of the drink and feed of the broiler chickens in comparison with the antibiotic “Maxus,” which is used in their diet, on a wide range of pathogenic microorganisms. It was shown that the number of bacteria in broilers was 1.88% when the nanocomposition was administered, which is more than two times less compared to the group in which the antibiotic was used.

Abstract Image

壳聚糖-纳米铜纳米组合物在肉仔鸡饲料中替代抗生素的研究
病原体对农业构成严重威胁,因为它们引起疾病,降低农场鸟类和动物的生长速度和效率,并造成经济损失。因此,抗生素继续被用于对抗病原体和预防,尽管它们有所有的负面影响和细菌对它们的耐药性。需要排除使用疫苗和药物的有效替代办法。制备了一种聚合稳定的壳聚糖与铜纳米粒子的纳米组合物,铜纳米粒子的平均粒径为25 ~ 30 nm。研究人员在体外对致病菌粪肠球菌的杀菌效果进行了研究,并在体内对肉鸡的饮料和饲料成分进行了研究,并与鸡粮中使用的抗生素“Maxus”进行了比较,研究了纳米组合物对多种致病菌的杀菌效果。结果表明,使用纳米组合物时肉鸡体内细菌数量为1.88%,比使用抗生素组减少了2倍以上。
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来源期刊
Applied Biochemistry and Microbiology
Applied Biochemistry and Microbiology 生物-生物工程与应用微生物
CiteScore
1.70
自引率
12.50%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.
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