The influence of chronic periodontitis and type 2 diabetes mellitus on resistin levels of gingival crevicular fluid- a systematic review and meta-analysis

Q1 Medicine

Journal of oral biology and craniofacial research Pub Date : 2025-04-08 DOI:10.1016/j.jobcr.2025.03.022

Dax Abraham , Alpa Gupta , Arun Kumar Duraisamy , Mrinalini Mrinalini

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引用次数: 0

Abstract

Aim

Chronic periodontitis (CP), a prevalent inflammatory dental disease, has been linked to systemic conditions like Type 2 Diabetes Mellitus (T2DM). This systematic review and meta-analysis aimed to evaluate resistin levels in the Gingival Crevicular Fluid (GCF) of CP individuals with T2DM. The objective was to determine if resistin could be a potential biomarker for periodontal disease in T2DM individuals.

Methods

The review included data from seventeen clinical studies that investigated resistin levels in GCF of individuals diagnosed with CP and T2DM. Data were sourced from PubMed, Scopus, and EBSCOhost, selected for their extensive coverage of medical and dental research, ensuring thorough retrieval of relevant studies. From the initial seventeen studies, five complied with the strict inclusion criteria for meta-analysis.

Results

Using a comprehensive meta-analysis, the significance of GCF Resistin levels in individuals with CP and T2DM relative to the healthy groups was examined. In addition, a meta-analysis was carried out to look into the relationship between periodontal probing depth (PPD) and CP and T2DM. The results indicated that individuals with T2DM and CP had significantly higher GCF resistin levels than the other groups. Furthermore, the PPD in T2DM with CP was significantly greater than in the other groups.

Conclusion

The present review highlights the potential role of resistin as a biomarker to diagnose individuals with chronic periodontitis and T2DM.

Clinical significance

The significantly elevated levels of resistin suggest that resistin could serve as a potential biomarker for T2DM in individuals with CP. This could lead to improved methods of early diagnosis and treatment, which could enhance individual outcomes and quality of life.

Prospero registration

The registration number CRD42023467186.

Abstract Image

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慢性牙周炎和2型糖尿病对龈沟液抵抗素水平的影响——一项系统综述和荟萃分析

慢性牙周炎（CP）是一种常见的炎症性牙病，与2型糖尿病（T2DM）等全身性疾病有关。本系统综述和荟萃分析旨在评估CP合并T2DM患者龈沟液（GCF）中的抵抗素水平。目的是确定抵抗素是否可能成为T2DM患者牙周病的潜在生物标志物。方法本综述纳入了17项临床研究的数据，这些研究调查了诊断为CP和T2DM的个体GCF中的抵抗素水平。数据来源于PubMed、Scopus和EBSCOhost，选择它们是因为它们广泛覆盖了医学和牙科研究，确保了相关研究的全面检索。从最初的17项研究中，有5项符合严格的meta分析纳入标准。结果通过综合荟萃分析，检验了CP和T2DM患者GCF抵抗素水平相对于健康组的意义。此外，我们还进行了荟萃分析，以探讨牙周探诊深度（PPD）与CP和T2DM之间的关系。结果表明，T2DM和CP患者GCF抵抗素水平明显高于其他组。T2DM合并CP组PPD明显高于其他组。结论本综述强调了抵抗素作为诊断慢性牙周炎和T2DM个体的生物标志物的潜在作用。抵抗素水平的显著升高表明抵抗素可以作为CP患者T2DM的潜在生物标志物，这可能导致早期诊断和治疗方法的改进，从而提高个体预后和生活质量。普洛斯彼罗注册注册号CRD42023467186。

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来源期刊

Journal of oral biology and craniofacial research Medicine-Otorhinolaryngology

CiteScore

4.90

自引率

0.00%

发文量

133

审稿时长

167 days

期刊介绍： Journal of Oral Biology and Craniofacial Research (JOBCR)is the official journal of the Craniofacial Research Foundation (CRF). The journal aims to provide a common platform for both clinical and translational research and to promote interdisciplinary sciences in craniofacial region. JOBCR publishes content that includes diseases, injuries and defects in the head, neck, face, jaws and the hard and soft tissues of the mouth and jaws and face region; diagnosis and medical management of diseases specific to the orofacial tissues and of oral manifestations of systemic diseases; studies on identifying populations at risk of oral disease or in need of specific care, and comparing regional, environmental, social, and access similarities and differences in dental care between populations; diseases of the mouth and related structures like salivary glands, temporomandibular joints, facial muscles and perioral skin; biomedical engineering, tissue engineering and stem cells. The journal publishes reviews, commentaries, peer-reviewed original research articles, short communication, and case reports.