Pregnancy-Induced Hypertension and Atherosclerotic Cardiovascular Disease Risk Score in China

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

CJC Open Pub Date : 2025-04-01 DOI:10.1016/j.cjco.2025.01.006

Honghong He MM , Junyan Sun MM , Hongqiu Huo MB , Yanxiu Wang MD , Yuntao Wu MM , Suhua Chen MB , Yangyang Wang MM , Xiaoming Zheng MD , Haiyan Zhao MD

{"title":"Pregnancy-Induced Hypertension and Atherosclerotic Cardiovascular Disease Risk Score in China","authors":"Honghong He MM , Junyan Sun MM , Hongqiu Huo MB , Yanxiu Wang MD , Yuntao Wu MM , Suhua Chen MB , Yangyang Wang MM , Xiaoming Zheng MD , Haiyan Zhao MD","doi":"10.1016/j.cjco.2025.01.006","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Pregnancy-induced hypertension (PIH) poses a significant threat to maternal health. This study aims to explore the association between PIH and the risk of atherosclerotic cardiovascular disease (ASCVD).</div></div><div><h3>Methods</h3><div>The cohort comprised 1947 pregnant women delivering a single child between 2004 and 2020 in the Kailuan study. Participants, categorized into PIH and non-PIH (NPIH) groups based on PIH history, completed questionnaires and underwent physical examinations and laboratory assessments within 2 years after delivery. Predicted ASCVD risks used the Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) model, distinguishing lifetime ASCVD risk as \"low\" (<32.8%) and \"high\" (≥32.8%). χ<sup>2</sup> tests and logistic regression were used to investigate the association between PIH and high lifetime risk China-PAR categories.</div></div><div><h3>Results</h3><div>Overall, 6.17% of the PIH group had high lifetime risk, compared with 0.96% in the NPIH group (χ<sup>2</sup> 29.59, <em>P</em> < 0.001). After adjusting for confounders, PIH was independently associated with high-risk China-PAR categories, with the PIH group having a 5.03 times higher probability than the NPIH group (95% CI 2.20-11.51, <em>P</em> < 0.01).</div></div><div><h3>Conclusion</h3><div>Pregnancy-induced hypertension was associated with increased lifetime risk of ASCVD.</div></div>","PeriodicalId":36924,"journal":{"name":"CJC Open","volume":"7 4","pages":"Pages 435-440"},"PeriodicalIF":2.5000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"CJC Open","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2589790X25000344","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Pregnancy-induced hypertension (PIH) poses a significant threat to maternal health. This study aims to explore the association between PIH and the risk of atherosclerotic cardiovascular disease (ASCVD).

Methods

The cohort comprised 1947 pregnant women delivering a single child between 2004 and 2020 in the Kailuan study. Participants, categorized into PIH and non-PIH (NPIH) groups based on PIH history, completed questionnaires and underwent physical examinations and laboratory assessments within 2 years after delivery. Predicted ASCVD risks used the Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) model, distinguishing lifetime ASCVD risk as "low" (<32.8%) and "high" (≥32.8%). χ² tests and logistic regression were used to investigate the association between PIH and high lifetime risk China-PAR categories.

Results

Overall, 6.17% of the PIH group had high lifetime risk, compared with 0.96% in the NPIH group (χ² 29.59, P < 0.001). After adjusting for confounders, PIH was independently associated with high-risk China-PAR categories, with the PIH group having a 5.03 times higher probability than the NPIH group (95% CI 2.20-11.51, P < 0.01).