The mediating role of the parietal-prefrontal white matter network between trauma experience and anxiety symptoms in individuals with borderline personality disorder: Findings from neuroimaging studies

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Psychiatry Research: Neuroimaging Pub Date : 2025-04-02 DOI:10.1016/j.pscychresns.2025.111987

Piotr Podwalski , Bartosz Dawidowski , Kamil Lipiński , Łukasz Franczak , Patryk Wysocki , Marcin Jabłoński , Adam Jędrzejewski , Piotr Plichta , Ernest Tyburski , Łukasz Zwarzany , Monika Szewczuk-Bogusławska , Błażej Misiak , Wojciech Poncyljusz , Jerzy Samochowiec

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引用次数: 0

Abstract

Background

Borderline personality disorder (BPD) is linked to impairments in white matter (WM) integrity, with traumatic experiences (TE) playing a key role in its development. As TE can affect brain structure, this study examined the parietal-prefrontal WM pathway, focusing on the superior longitudinal fasciculus (SLF), the longest association bundle, to explore WM integrity impairments and their link to BPD symptoms.

Methodology

The study included 90 women (47 with BPD, 43 healthy controls). Participants underwent psychopathology assessments and diffusion tensor imaging (DTI) to measure WM integrity. Mean fractional anisotropy (FA) values were calculated for SLF subdivisions (SLF I, II, III). BPD symptoms were evaluated using the Five-Factor Borderline Inventory.

Results

Healthy controls showed significantly higher FA in the left SLF I and a trend toward higher FA in the left SLF III compared to BPD. Left SLF I FA mediated the link between trauma (e.g., sexual harassment, emotional/physical abuse) and BPD symptoms (despondence, fragility). Left SLF III FA mediated the relationship between sexual harassment and anxious uncertainty.

Conclusion

The SLF mediates the impact of TE on anxiety and depression in BPD, highlighting neurobiological mechanisms and potential research directions.

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边缘型人格障碍患者创伤经历和焦虑症状之间顶叶-前额叶白质网络的中介作用：来自神经影像学研究的发现

边缘型人格障碍（BPD）与白质（WM）完整性受损有关，创伤经历（TE）在其发展中起着关键作用。由于TE可以影响大脑结构，本研究检查了顶叶-前额叶WM通路，重点关注最长的关联束上纵束（SLF），以探索WM完整性受损及其与BPD症状的联系。方法本研究纳入90名女性（47名BPD患者，43名健康对照）。参与者接受了精神病理评估和弥散张量成像（DTI）来测量WM的完整性。计算SLF细分（SLF I、II、III）的平均分数各向异性（FA）值。使用五因素边界量表评估BPD症状。结果与BPD相比，健康对照组的左SLF I和左SLF III的FA均有显著升高的趋势。左SLF I FA介导了创伤（如性骚扰、情绪/身体虐待）和BPD症状（沮丧、脆弱）之间的联系。左SLF III FA在性骚扰与焦虑不确定性的关系中起中介作用。结论SLF介导TE对BPD患者焦虑和抑郁的影响，突出了神经生物学机制和潜在的研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychiatry Research: Neuroimaging 医学-精神病学

CiteScore

3.80

自引率

0.00%

发文量

审稿时长

22.5 weeks

期刊介绍： The Neuroimaging section of Psychiatry Research publishes manuscripts on positron emission tomography, magnetic resonance imaging, computerized electroencephalographic topography, regional cerebral blood flow, computed tomography, magnetoencephalography, autoradiography, post-mortem regional analyses, and other imaging techniques. Reports concerning results in psychiatric disorders, dementias, and the effects of behaviorial tasks and pharmacological treatments are featured. We also invite manuscripts on the methods of obtaining images and computer processing of the images themselves. Selected case reports are also published.