3D printed mucoadhesive bupropion hydrochloride buccal thin films using Liquid Crystal Display

Abstract

Oromucosal delivery of active pharmaceutical ingredients offers a promising alternative method of administration, as it bypasses the first-pass metabolism and enhances patient compliance especially for people who have difficulties swallowing. In this study, liquid crystal display (LCD) 3D printing was explored as an additive manufacturing process for producing mucoadhesive thin films of various sizes containing bupropion hydrochloride (BUP·HCl). For this purpose, poly(ethylene) oxide (polyox 10N) was used as a mucoadhesion enhancer, while PEG200 was used as a plasticizer to form flexible BUP·HCl buccal films, and PEGDA700 served as a crosslinking agent. Solid-state analysis was carried out using differential scanning calorimetry (DSC and X-ray diffraction) which showed that BUP·HCl was in amorphous state within the printed films.

The swelling ratio of the thin films varied from 0.9 to 1.3 while ink composition resulted peak adhesive force values of 0.37–0.52Nmm and cohesiveness values between 8 and 9 mm affected by the content of poly(ethylene)oxide. Dissolution studies in simulated saliva showed immediate release for all the BUP·HCl thin films while the ex vivo permeability in porcine buccal epithelium revealed 52 % permeation within 120 min. The results demonstrated that LCD printing technology is a robust, time-efficient, and high precision technology that can be used for the design of personalized medications.