Electrophilic thiocyanation of aromatic, heteroaromatic and aliphatic compounds: A novel perspective on recent advances

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-04-03 DOI:10.1016/j.tet.2025.134645

Sobhan Rezayati , Maryam Manafi Moghadam , Ali Ramazani , Guoying Zhang

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Abstract

One important technique in organic chemistry that makes it easier to create thiocyanate derivatives from aliphatic, aromatic and heteroaromatic molecules is electrophilic thiocyanation. In our earlier article, we explored the foundational concepts and approaches for synthesizing thiocyanates. This study offers a comprehensive and analytical review of the latest advancements in this field. We explore innovative trends, key drivers, and factors influencing the reaction conditions that have enhanced the yield and selectivity of these reactions. Additionally, we examine current research and present fresh ideas that weren't as prominent in our earlier work. Here, we shall categorize a broad range of techniques for the production of aromatic and heteroaromatic thiocyanate derivatives that have been developed over the last four years based on different catalysts. In addition to compiling the body of knowledge, this article helps scholars become acquainted with recent developments in electrophilic thiocyanation and pinpoint areas for further investigation.

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芳香族、杂芳香族和脂肪族化合物的亲电硫氰化：最新进展的新视角

亲电硫氰化是有机化学中一项重要的技术，它使从脂肪族、芳香族和异芳香族分子中更容易产生硫氰酸盐衍生物。在我们之前的文章中，我们探讨了合成硫氰酸酯的基本概念和方法。本研究对该领域的最新进展进行了全面的分析性回顾。我们探索了提高这些反应收率和选择性的创新趋势、关键驱动因素和影响反应条件的因素。此外，我们还研究了当前的研究，并提出了在我们早期工作中不那么突出的新观点。在这里，我们将对过去四年中基于不同催化剂开发的芳香族和异芳香族硫氰酸酯衍生物的广泛生产技术进行分类。除了汇编知识体，本文帮助学者熟悉亲电硫氰化的最新发展，并指出进一步研究的领域。

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.