Impact of weightlessness on dynamic deformation and haemodynamic parameters of the heart

IF 2.9 3区生物学 Q2 ASTRONOMY & ASTROPHYSICS

Life Sciences in Space Research Pub Date : 2025-04-04 DOI:10.1016/j.lssr.2025.03.011

Li Cai , Jing Xue , Yongheng Wang , Youqiong Liu , Hao Gao

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引用次数: 0

Abstract

Cardiovascular disease remains an important challenge for human space travel, it is particularly important for astronaut health to accurately simulate cardiac conditions in weightless environments. In this study, a coupled flow-solid model of the left ventricular (LV) and mitral valve (MV) is developed by the immersed boundary/finite element (IB/FE) method, and the boundary conditions of the model were determined from the relationship between gravitational level, LV sphericity and LV end-diastolic pressure. Based on this model, the dynamic deformation and haemodynamic parameters of the LV and the MV are investigated in different gravitational environments, such as Zero Gravity, the Moon (0.167 g), the Mars (0.38 g) and the Earth. The validity and accuracy of the model is verified by comparing the Zero Gravity simulation results with the real data obtained from the space flight experiment. The prediction results of the model can provide some references on how to combat the adverse effects of weightlessness during spaceflight.

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来源期刊

Life Sciences in Space Research Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

CiteScore

5.30

自引率

8.00%

发文量

期刊介绍： Life Sciences in Space Research publishes high quality original research and review articles in areas previously covered by the Life Sciences section of COSPAR''s other society journal Advances in Space Research. Life Sciences in Space Research features an editorial team of top scientists in the space radiation field and guarantees a fast turnaround time from submission to editorial decision.