MMP-9 Expression in bone cells in the developing femur

IF 2.7 4区生物学 Q1 ANATOMY & MORPHOLOGY

Tissue & cell Pub Date : 2025-03-28 DOI:10.1016/j.tice.2025.102862

Fatma El-Zahraa A. Mustafa , Hanan H. Abd-Elhafeez , Reda S. taha , Amira Osman , Mohamed M. Almaki , Zyad Mohamed Baker , Abdullah A.A. Alghamdi , Diaa Massoud , Mohamad Elmasry , Soha A. Soliman , Abeer Madkour Mahmoud

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引用次数: 0

Abstract

The proteolytic functions of the matrix-degrading enzymes, such as ADAMTS (A disintegrin and metalloproteinases) and MMP (Matrix metalloproteinase), play a crucial role in development. This study investigated the proteolytic activity of different types of bone cells, focusing on the expression of MMP-9, throughout the development of the femur in rabbit embryos. The femur formed the physeal growth cartilage, which facilitated the process of endochondral bone development. Osteoblasts are situated on the outer layer of bone spicules and within the periosteum. Osteoclasts are found within the lacunae of the bone matrix, and they have also been observed in the ossification center. Osteoclasts, osteocytes, and osteoblasts all exhibit MMP-9 expression with different intensity of staining with the perichondral stem cells showing the greatest value. MMP-9 is essential in bone formation. Utilizing MMP-9 to modify the extracellular matrix could potentially serve as a favorable approach for identifying treatment targets in bone diseases.

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.