Sinomenine Inhibits TOPK To Ameliorate Psoriasiform Dermatitis

Abstract

Psoriasis is an inflammatory skin disease. Sinomenine is an alkaloid extracted from the rhizome of Sinomenium acutum. Sinomenine plays an important role in inhibiting skin inflammation. However, the mechanism and targets of sinomenine in psoriasis remain unclear. In this study, we found that sinomenine bound and inhibited the TOPK activity in vitro. Moreover, sinomenine inhibited TOPK activation ex and in vivo. Furthermore, sinomenine ameliorated the psoriasiform phenotype in vitro and in vivo. In this study, we determined that TOPK is a potential target of sinomenine to alleviate psoriatic skin inflammation and to provide new processes for clinical treatment.