One-Component Ionizable Amphiphilic Janus Dendrimers for Targeted mRNA Delivery

Abstract

mRNA nanomedicine represents a new generation of therapeutics. However, how to deliver mRNA to the desired organs and cells effectively remains challenging. Common mRNA delivery vectors include viral and non-viral types such as four-component lipid nanoparticles (LNPs), polymer based nanoparticles, lipid-polymer hybrid nanoparticles and so on. One-component ionizable amphiphilic Janus dendrimers (IAJDs), are an emerging type of mRNA delivery vehicle displaying good stability and high delivery efficiency. In this review, we comprehensively present the design, synthesis and mRNA delivery properties of IAJDs, with particular focus on the relationship between their molecular structures and organ targeted delivery properties. Other representative types of dendrimers for RNA delivery are also reviewed. Overall, this review summarizes the recent research progress on IAJDs systematically, aiming to guide the development of more efficient mRNA delivery platforms and next-generation mRNA nanomedicines.