Controlling pyroptosis through post-translational modifications of gasdermin D

IF 10.7 1区生物学 Q1 CELL BIOLOGY

Developmental cell Pub Date : 2025-04-07 DOI:10.1016/j.devcel.2025.02.005

Na Zhang, Daichao Xu

引用次数: 0

Abstract

Pyroptosis, a lytic and programmed cell death pathway, is mediated by gasdermins (GSDMs), with GSDMD playing an important role in innate immunity and pathology. Upon activation, GSDMD is cleaved to release the active N-terminal fragment that oligomerizes into membrane pores, which promote pyroptosis and cytokine secretion, leading to inflammation. Emerging evidence indicates that post-translational modification (PTM) is an important regulatory mechanism of GSDMD activity. This review explores how PTMs, aside from proteolytic cleavage, control GSDMD activity and link biological contexts to pyroptosis in innate immunity and inflammation, which could inform future studies and therapeutic solutions for treating inflammatory conditions.

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通过翻译后修饰气皮蛋白D控制焦亡

焦亡（pyptosis）是一种裂解性和程序性细胞死亡途径，由gasdermins （GSDMs）介导，GSDMD在先天免疫和病理中起重要作用。激活后，GSDMD被裂解，释放活性n端片段，寡聚进入膜孔，促进热亡和细胞因子分泌，导致炎症。越来越多的证据表明，翻译后修饰（PTM）是GSDMD活性的重要调控机制。这篇综述探讨了除了蛋白水解裂解外，PTMs如何控制GSDMD活性，并将生物学背景与先天免疫和炎症中的焦亡联系起来，这可能为未来的研究和治疗炎症疾病的治疗方案提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Developmental cell 生物-发育生物学

CiteScore

18.90

自引率

1.70%

发文量

203

审稿时长

3-6 weeks

期刊介绍： Developmental Cell, established in 2001, is a comprehensive journal that explores a wide range of topics in cell and developmental biology. Our publication encompasses work across various disciplines within biology, with a particular emphasis on investigating the intersections between cell biology, developmental biology, and other related fields. Our primary objective is to present research conducted through a cell biological perspective, addressing the essential mechanisms governing cell function, cellular interactions, and responses to the environment. Moreover, we focus on understanding the collective behavior of cells, culminating in the formation of tissues, organs, and whole organisms, while also investigating the consequences of any malfunctions in these intricate processes.