Obstructive Sleep Apnea Syndrome in Chronic Total Occlusion Percutaneous Coronary Intervention; Insights from the PROGRESS-CTO registry.

IF 2.7 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Hellenic Journal of Cardiology Pub Date : 2025-04-02 DOI:10.1016/j.hjc.2025.03.010

Ozgur Selim Ser, Deniz Mutlu, Michaella Alexandrou, Pedro E P Carvalho, Dimitrios Strepkos, James W Choi, Paul Poommipanit, Khaldoon Alaswad, Mir Babar Basir, Rhian Davies, Farouc A Jaffer, Phil Dattilo, Anthony H Doing, Lorenzo Azzalini, Nazif Avgul, Raj H Chandwaney, Brian K Jefferson, Sevket Gorgulu, Jaikirshan J Khatri, Laura D Young, Oleg Krestyaninov, Dmitrii Khelimski, Jarrod Frizzell, Omer Goktekin, James D Flaherty, Daniel R Schimmel, Keith H Benzuly, Mahmut Uluganyan, Ramazan Ozdemir, Yousif Ahmad, Sant Kumar, Bavana V Rangan, Olga C Mastrodemos, M Nicholas Burke, Sandeep Jalli, Konstantinos Voudris, Yader Sandoval, Emmanouil S Brilakis

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引用次数: 0

Abstract

Background: The outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in patients with obstructive sleep apnea syndrome (OSAS) have received limited study.

Methods: We compared the procedural characteristics and outcomes of CTO PCIs in patients with and without OSAS in a multicenter registry.

Results: Of 7,403 patients who underwent 7,408 CTO PCIs between 2012 and 2024 at 47 centers, 942 (13%) had OSAS. Compared with patients without OSAS, patients with OSAS were older; more likely to be men; and had higher prevalence of diabetes, hypertension, dyslipidemia, cerebrovascular disease, previous heart failure, coronary artery bypass graft surgery, and previous PCI. They had higher J-CTO (2.73±1.20 vs. 2.30±1.25; p<0.001) and PROGRESS-CTO (1.35±1.01 vs. 1.16±0.96; p<0.001) scores, longer lesion length, and more complex angiographic characteristics. Compared with patients without OSAS, patients with OSAS had similar technical success (87.6% vs. 88.3%, p = 0.552) and procedural success (85.9% vs. 87.2%, p = 0.260). There were no differences in terms of in hospital MACEs and death. After a median follow-up of 71 days, the incidence of MACEs (3.9% vs 1.6%, p = 0.026) and death (2.6% vs 0.6%, p=0.003) was higher in patients with OSAS than in patients without OSAS. In the multivariable analysis, OSAS was independently associated with higher follow-up MACEs (hazard ratio 2.32, 95% confidence intervals 1.22-3.26, p=0.006).

Conclusions: OSAS is common in patients undergoing CTO PCI. Compared with patients without OSAS, patients with OSAS had more comorbidities and more complex CTOs, similar rates of periprocedural success and complications, and higher rates of follow-up MACEs.

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来源期刊

Hellenic Journal of Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.90

自引率

7.30%

发文量

审稿时长

56 days

期刊介绍： The Hellenic Journal of Cardiology (International Edition, ISSN 1109-9666) is the official journal of the Hellenic Society of Cardiology and aims to publish high-quality articles on all aspects of cardiovascular medicine. A primary goal is to publish in each issue a number of original articles related to clinical and basic research. Many of these will be accompanied by invited editorial comments. Hot topics, such as molecular cardiology, and innovative cardiac imaging and electrophysiological mapping techniques, will appear frequently in the journal in the form of invited expert articles or special reports. The Editorial Committee also attaches great importance to subjects related to continuing medical education, the implementation of guidelines and cost effectiveness in cardiology.