Genomically recoded organisms: redefining and safeguarding biological systems.

IF 14.3 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2025-05-01 Epub Date: 2025-04-03 DOI:10.1016/j.tibtech.2025.03.014

Miriam Amiram

引用次数: 0

Abstract

In a recent report, Grome et al. describe a genomically recoded Escherichia coli strain with a 62-codon genome and a single stop codon. This and other genomically recoded organisms (GROs), engineered with modified genetic vocabularies, enable the creation of novel proteins and biomaterials, while ensuring the safety and viability of GRO-based biomanufacturing.

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基因组编码生物体：重新定义和保护生物系统。

在最近的一份报告中，Grome等人描述了一种基因组编码的大肠杆菌菌株，该菌株具有62个密码子基因组和一个停止密码子。这种和其他基因组编码生物（GROs），用修改的遗传词汇进行工程改造，能够创造新的蛋白质和生物材料，同时确保基于GROs的生物制造的安全性和可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).