Epicardial fat thickness is increased in menopausal patients in comparison with premenopausal patients with similar excess weight: a cross-sectional study.

IF 6.1 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Elena Gangitano, Giuseppe Barbaro, Lucio Gnessi, Gianluca Iacobellis, Carla Lubrano
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引用次数: 0

Abstract

Background: The prevalence of excess weight and ageing is notably high in contemporary Western societies. The effectiveness of body mass index (BMI) and waist circumference as tools for identifying excess weight and ectopic fat deposition, both associated with an increased cardiovascular risk, is questionable.

Methods: Our objective is to compare women affected by overweight and obesity during fertile years and menopausal time and identify easily accessible clinical parameters associated with ectopic fat deposition, providing valuable insights into cardiovascular risk. Over 1300 female patients with excess weight referred to the CASCO Centre (High Specialization Centre for the Care of Obesity) at Umberto I Polyclinic in Rome, Italy, were included. Each participant underwent a DXA scan and a cardiac ultrasound, and blood tests to verify menopausal status and evaluate metabolic profile and hepatic steatosis through indirect measurements.

Results: 775 patients were in the pre-menopausal phase and 617 in the post-menopausal phase. The two cohorts did not differ in BMI, total body fat and lean mass, or waist circumference. However, the post-menopausal group showed an increased visceral fat deposition, evaluated by waist-to-hip ratio and epicardial fat thickness (EFT), and a worse metabolic profile.

Conclusion: Menopause is associated with a worsening of the metabolic features observed in obesity, with an increase in visceral fat deposition. Of note, these alterations are more pronounced despite similar BMI and waist circumference.

与绝经前体重超标情况相似的患者相比,绝经患者的心外膜脂肪厚度增加:一项横断面研究。
背景:在当代西方社会中,超重和老龄化的患病率非常高。体重指数(BMI)和腰围作为识别超重和异位脂肪沉积(两者都与心血管风险增加有关)的工具的有效性值得怀疑。方法:我们的目的是比较育龄期和绝经期受超重和肥胖影响的妇女,并确定与异位脂肪沉积相关的容易获得的临床参数,为心血管风险提供有价值的见解。在意大利罗马Umberto I综合医院的CASCO中心(肥胖护理高级专业中心),有1300多名超重女性患者被纳入研究。每位参与者都进行了DXA扫描和心脏超声检查,并进行了血液检查,以验证绝经状态,并通过间接测量评估代谢谱和肝脂肪变性。结果:绝经前期775例,绝经后期617例。这两个队列在体重指数、总脂肪和瘦质量或腰围方面没有差异。然而,绝经后组显示内脏脂肪沉积增加,通过腰臀比和心外膜脂肪厚度(EFT)来评估,代谢谱更差。结论:绝经与肥胖代谢特征的恶化有关,内脏脂肪沉积增加。值得注意的是,尽管BMI和腰围相似,但这些变化更为明显。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Translational Medicine
Journal of Translational Medicine 医学-医学:研究与实验
CiteScore
10.00
自引率
1.40%
发文量
537
审稿时长
1 months
期刊介绍: The Journal of Translational Medicine is an open-access journal that publishes articles focusing on information derived from human experimentation to enhance communication between basic and clinical science. It covers all areas of translational medicine.
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