Initiation of enteral feeding as per current protocol (at 24 h) versus as per clinical status (from 6 h onwards) in neonates born with antenatal reversed end diastolic flow (REDF) in the umbilical artery Doppler: a pilot randomized controlled trial.

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2025-04-06 DOI:10.1038/s41372-025-02288-z

Rishi Kathuria, Kanya Mukhopadhyay

{"title":"Initiation of enteral feeding as per current protocol (at 24 h) versus as per clinical status (from 6 h onwards) in neonates born with antenatal reversed end diastolic flow (REDF) in the umbilical artery Doppler: a pilot randomized controlled trial.","authors":"Rishi Kathuria, Kanya Mukhopadhyay","doi":"10.1038/s41372-025-02288-z","DOIUrl":null,"url":null,"abstract":"Objective: To compare the effects of initiating feeds at 24 h versus at 6 h in neonates with reversed end-diastolic flow (REDF) and determine the incidence of feed intolerance (FI) and necrotizing enterocolitis (NEC).Design: Pilot randomized controlled trial.Methods: Neonates with REDF (n = 52) were randomized to start feeds at 6 h (n = 26) or 24 h (n = 26) to assess FI, NEC, time to full feeds, sepsis, mortality, weight and gestation at discharge, and hospital stay.Results: FI was observed in 14 (54%) neonates in 6 h group and 17 (65%) in 24 h group, with comparable NEC rates. Neonates in the 6 h group achieved full feeds faster (8 vs. 11 days) and had shorter hospital stay (17 vs. 32 days). Death and sepsis rates were similar.Conclusions: Feed initiation at 6 h in REDF neonates did not increase the risk of FI or NEC.Trial registration: Clinical trial registry of India (CTRI/2023/02/050025); 23/02/2023.","PeriodicalId":16690,"journal":{"name":"Journal of Perinatology","volume":" ","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Perinatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41372-025-02288-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To compare the effects of initiating feeds at 24 h versus at 6 h in neonates with reversed end-diastolic flow (REDF) and determine the incidence of feed intolerance (FI) and necrotizing enterocolitis (NEC).

Design: Pilot randomized controlled trial.

Methods: Neonates with REDF (n = 52) were randomized to start feeds at 6 h (n = 26) or 24 h (n = 26) to assess FI, NEC, time to full feeds, sepsis, mortality, weight and gestation at discharge, and hospital stay.

Results: FI was observed in 14 (54%) neonates in 6 h group and 17 (65%) in 24 h group, with comparable NEC rates. Neonates in the 6 h group achieved full feeds faster (8 vs. 11 days) and had shorter hospital stay (17 vs. 32 days). Death and sepsis rates were similar.

Conclusions: Feed initiation at 6 h in REDF neonates did not increase the risk of FI or NEC.

Trial registration: Clinical trial registry of India (CTRI/2023/02/050025); 23/02/2023.

查看原文本刊更多论文

根据现行方案（24小时）与根据临床状态（从6小时开始）在脐动脉多普勒中出生的产前舒张末期血流逆转（REDF）的新生儿中开始肠内喂养：一项随机对照试验。

目的：比较24 h和6 h开始喂养对舒张末血流逆转（REDF）新生儿的影响，并确定饲料不耐受（FI）和坏死性小肠结肠炎（NEC）的发生率。设计：先导随机对照试验。方法：将52例REDF新生儿随机分为6 h （n = 26）和24 h （n = 26）开始喂养，评估FI、NEC、完全喂养时间、败血症、死亡率、出院时体重和妊娠情况以及住院时间。结果：6 h组14例（54%）新生儿出现FI， 24 h组17例（65%）新生儿出现FI，两者NEC发生率相当。6小时组的新生儿获得完全喂养更快（8天对11天），住院时间更短（17天对32天）。死亡率和败血症率相似。结论：REDF新生儿6小时开始喂养不会增加FI或NEC的风险。试验注册：印度临床试验注册中心（CTRI/2023/02/050025）；23/02/2023。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.