Association between lipid accumulation product (LAP) index and self-reported oral health outcomes: a cross-sectional study.

IF 3.9 2区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Li Shuning, Yang Wei, Fan Xuhui, Dong Jianfeng, Liu Jilun
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引用次数: 0

Abstract

Background: Lipid Accumulation Product (LAP) is a biomarker associated with excessive lipid accumulation and various metabolic diseases. Despite the well-established link between oral and systemic health, the association between LAP and oral health remains largely unexplored.

Methods: Data from 7,124 participants aged over 18 years from the National Health and Nutrition Examination Survey (NHANES) between 2009 and 2014 were analyzed. Multivariate logistic regression models were applied to evaluate the independent association between LAP and self-reported oral health outcomes, adjusting for potential confounders.

Results: There was a significant correlation between increasing LAP levels and deteriorating oral health status (β = 0.26, 95% CI: 0.20 to 0.32, P < 0.0001). Subgroup analyses revealed that the negative correlation between LAP and self-reported oral health outcomes was more pronounced in younger individuals and those with higher education levels. A non-linear relationship was identified, with oral health deteriorating significantly as LAP increased up to a threshold of 83, after which the relationship became non-significant.

Conclusions: This study demonstrates a robust association between LAP and self-reported oral health outcomes, suggesting that LAP could be a reliable indicator for assessing oral health status. The findings highlight the importance of targeted health interventions for populations with higher LAP indices to prevent oral health deterioration and potential systemic health issues.

脂质积累产物(LAP)指数与自我报告的口腔健康结果之间的关系:一项横断面研究
背景:脂质积累产物(LAP)是一种与过度脂质积累和各种代谢疾病相关的生物标志物。尽管口腔和全身健康之间的联系已经确立,但LAP与口腔健康之间的关系在很大程度上仍未被探索。方法:对2009年至2014年全国健康与营养调查(NHANES)中7124名18岁以上参与者的数据进行分析。应用多变量logistic回归模型评估LAP与自我报告口腔健康结果之间的独立关联,并对潜在混杂因素进行调整。结果:LAP水平升高与口腔健康状况恶化之间存在显著相关性(β = 0.26, 95% CI: 0.20 ~ 0.32, P)。结论:本研究表明LAP与自我报告的口腔健康结果之间存在显著相关性,提示LAP可作为评估口腔健康状况的可靠指标。研究结果强调了对LAP指数较高的人群进行有针对性的健康干预的重要性,以防止口腔健康恶化和潜在的全身健康问题。
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来源期刊
Lipids in Health and Disease
Lipids in Health and Disease 生物-生化与分子生物学
CiteScore
7.70
自引率
2.20%
发文量
122
审稿时长
3-8 weeks
期刊介绍: Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.
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