Unveiling trends in urinary tract cancer mortality among older adults in the United States (1999-2022): a CDC WONDER perspective.

IF 1.8 4区医学 Q3 UROLOGY & NEPHROLOGY

International Urology and Nephrology Pub Date : 2025-04-05 DOI:10.1007/s11255-025-04490-6

Laksh Kumar, Talha Ali, Faiqa Iqbal, Muhammad Ahmed, Bazil Azeem

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引用次数: 0

Abstract

Background: Urinary tract cancers (UTCs), including bladder cancer, remain a significant public health challenge, particularly among individuals aged 75 and older. Despite declining bladder cancer-specific mortality rates between 2015 and 2020, the broader trends in UTC mortality and associated demographic disparities remain underexplored.

Methods: We analyzed mortality data from 1999 to 2022 using the CDC WONDER database. UTC deaths were identified using ICD- 10 codes C64 to C68. Age-adjusted mortality rates (AAMRs) per 100,000 population were calculated, stratified by sex, race/ethnicity, and census regions. Joinpoint regression identified annual percent changes (APCs) to assess temporal trends.

Results: From 1999 to 2022, 477,157 UTC deaths were recorded, 66% of which occurred among individuals aged 75 and older. The AAMR increased from 97.1 in 1999 to 103.5 in 2022, with a rise between 1999 and 2007 (APC: 0.63%), a decline from 2007 to 2019 (APC: - 0.33%), and a resurgence from 2019 to 2022 (APC: 2.42%). Older males exhibited higher AAMRs than females (178.7 vs. 53.6 in 2022), and Whites had the highest AAMR (108.5) among racial groups. The Western region recorded the highest AAMR (84.3) during the study period.

Conclusion: The resurgence in UTC mortality post- 2019 highlights emerging challenges, particularly among older males, Whites, and residents of the Western region. Targeted interventions, including improved screening and equitable healthcare access, are essential to mitigate these disparities and improve outcomes.

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揭示美国老年人尿路癌死亡率的趋势（1999-2022）：CDC WONDER的视角

背景：尿路癌（UTCs），包括膀胱癌，仍然是一个重大的公共卫生挑战，特别是在75岁及以上的人群中。尽管膀胱癌特异性死亡率在2015年至2020年间有所下降，但UTC死亡率的更广泛趋势和相关的人口差异仍未得到充分探讨。方法：使用CDC WONDER数据库分析1999 - 2022年的死亡率数据。使用ICD- 10代码C64至C68确定UTC死亡。按性别、种族/民族和人口普查地区，计算每10万人的年龄调整死亡率（AAMRs）。连接点回归确定了年度百分比变化（APCs）来评估时间趋势。结果：从1999年到2022年，记录了477,157例UTC死亡，其中66%发生在75岁及以上的个体中。AAMR从1999年的97.1上升到2022年的103.5，其中1999 - 2007年上升（APC: 0.63%）， 2007 - 2019年下降（APC: - 0.33%）， 2019 - 2022年回升（APC: 2.42%）。老年男性的AAMR高于女性（2022年为178.7比53.6），白人的AAMR最高（108.5）。西部地区的AAMR最高，为84.3。结论：2019年后UTC死亡率的回升凸显了新出现的挑战，特别是在老年男性、白人和西部地区的居民中。有针对性的干预措施，包括改进筛查和公平获得医疗服务，对于减轻这些差距和改善结果至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Urology and Nephrology 医学-泌尿学与肾脏学

CiteScore

3.40

自引率

5.00%

发文量

329

审稿时长

1.7 months

期刊介绍： International Urology and Nephrology publishes original papers on a broad range of topics in urology, nephrology and andrology. The journal integrates papers originating from clinical practice.