Association between Trichomonas vaginalis infection and spontaneous preterm labour in Lagos, Nigeria: an analytical cross-sectional study.

IF 1.6 Q2 MULTIDISCIPLINARY SCIENCES

BMC Research Notes Pub Date : 2025-04-05 DOI:10.1186/s13104-025-07196-1

Oyebola H Sunmonu, Kehinde S Okunade, Omololu Adegbola

{"title":"Association between Trichomonas vaginalis infection and spontaneous preterm labour in Lagos, Nigeria: an analytical cross-sectional study.","authors":"Oyebola H Sunmonu, Kehinde S Okunade, Omololu Adegbola","doi":"10.1186/s13104-025-07196-1","DOIUrl":null,"url":null,"abstract":"Background: Preterm labour (PTL) leading to preterm birth is a grave complication of pregnancy that attracts long-term medical and social sequelae. However, there is still a paucity of data on the impact of Trichomonas vaginalis infection on PTL especially among women in sub-Saharan Africa.Objective: This study determined the association between T. vaginalis infection and PTL among pregnant women in Lagos, Southwest, Nigeria using a molecular-based rapid antigen detection technique to diagnose T. vaginalis infection.Methods: This was a multicenter analytical cross-sectional study carried out among parturients managed in the labour ward units of three hospitals in Lagos, Southwest Nigeria between April and December 2019. High vaginal swab samples were collected from n = 105 pregnant women with PTL and an equal number of women who had term labour between April and December 2019. T. vaginalis Antigen Rapid test was used for the detection of T. vaginalis in the vaginal samples. Multivariable binary logistic regression analyses were used to control for all potential confounders in the association between T. vaginalis infection and PTL. Statistical significance was reported at p < 0.05.Results: The prevalence of T. vaginalis infection was significantly higher in women with PTL compared to those with term labour (12.4% vs. 2.9%, p = 0.009). On adjustments for age, parity, booking and educational status, abnormal vaginal discharge and occurrence of prelabour rupture of membranes, there was no association between T. vaginalis infection and PTL (adjusted Odds ratio = 0.94, 95% CI: 0.10-9.29).Conclusions: The study showed no independent association between T. vaginalis and PTL. We recommend future adequately powered longitudinal studies with consideration for other potential confounding factors, such as sexual lifestyle and STIs, to further explore any potential relationship between T. vaginalis and PTL.","PeriodicalId":9234,"journal":{"name":"BMC Research Notes","volume":"18 1","pages":"142"},"PeriodicalIF":1.6000,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972537/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Research Notes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1186/s13104-025-07196-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Preterm labour (PTL) leading to preterm birth is a grave complication of pregnancy that attracts long-term medical and social sequelae. However, there is still a paucity of data on the impact of Trichomonas vaginalis infection on PTL especially among women in sub-Saharan Africa.

Objective: This study determined the association between T. vaginalis infection and PTL among pregnant women in Lagos, Southwest, Nigeria using a molecular-based rapid antigen detection technique to diagnose T. vaginalis infection.

Methods: This was a multicenter analytical cross-sectional study carried out among parturients managed in the labour ward units of three hospitals in Lagos, Southwest Nigeria between April and December 2019. High vaginal swab samples were collected from n = 105 pregnant women with PTL and an equal number of women who had term labour between April and December 2019. T. vaginalis Antigen Rapid test was used for the detection of T. vaginalis in the vaginal samples. Multivariable binary logistic regression analyses were used to control for all potential confounders in the association between T. vaginalis infection and PTL. Statistical significance was reported at p < 0.05.

Results: The prevalence of T. vaginalis infection was significantly higher in women with PTL compared to those with term labour (12.4% vs. 2.9%, p = 0.009). On adjustments for age, parity, booking and educational status, abnormal vaginal discharge and occurrence of prelabour rupture of membranes, there was no association between T. vaginalis infection and PTL (adjusted Odds ratio = 0.94, 95% CI: 0.10-9.29).

Conclusions: The study showed no independent association between T. vaginalis and PTL. We recommend future adequately powered longitudinal studies with consideration for other potential confounding factors, such as sexual lifestyle and STIs, to further explore any potential relationship between T. vaginalis and PTL.

查看原文本刊更多论文

在拉各斯，尼日利亚阴道毛滴虫感染和自发性早产之间的关系：一项分析横断面研究。

背景：早产（PTL）导致早产是妊娠的严重并发症，引起长期的医疗和社会后遗症。然而，关于阴道毛滴虫感染对PTL的影响的数据仍然缺乏，特别是在撒哈拉以南非洲的妇女中。目的：应用分子快速抗原检测技术诊断尼日利亚西南部拉各斯地区孕妇阴道生殖道绦虫感染与PTL的关系。方法：这是一项多中心分析横断面研究，于2019年4月至12月在尼日利亚西南部拉各斯三家医院的产房单元进行管理。从2019年4月至12月期间n = 105名患有PTL的孕妇和同等数量的足月分娩妇女中收集了大量阴道拭子样本。采用阴道t型绦虫抗原快速试验检测阴道标本中的阴道t型绦虫。采用多变量二元logistic回归分析来控制阴道t细胞感染与PTL之间关联的所有潜在混杂因素。结果：PTL患者阴道生殖道绦虫感染率明显高于足月分娩患者（12.4% vs. 2.9%, p = 0.009）。经年龄、胎次、预约和教育程度、阴道分泌物异常和产前胎膜破裂的发生等因素调整后，阴道绦虫感染与PTL无关联（调整后优势比= 0.94,95% CI: 0.10-9.29）。结论：本研究未发现阴道t型绦虫与PTL之间存在独立关联。我们建议未来进行足够有力的纵向研究，考虑其他潜在的混杂因素，如性生活方式和性传播感染，以进一步探索阴道t型炎与PTL之间的潜在关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

BMC Research Notes Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

3.60

自引率

0.00%

发文量

363

审稿时长

15 weeks

期刊介绍： BMC Research Notes publishes scientifically valid research outputs that cannot be considered as full research or methodology articles. We support the research community across all scientific and clinical disciplines by providing an open access forum for sharing data and useful information; this includes, but is not limited to, updates to previous work, additions to established methods, short publications, null results, research proposals and data management plans.