Combination of the microalga Pavlova sp. OPMS 30543 with diclofenac attenuates hyperalgesia in adjuvant-induced arthritis mice.

IF 1.4 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioscience, Biotechnology, and Biochemistry Pub Date : 2025-04-04 DOI:10.1093/bbb/zbaf047

Wataru Nemoto, Kotaro Yamada, Ruka Kobayashi, Tomohiro Hoshi, Ken Nakahara, Akihiko Kanamoto, Osamu Nakagawasai, Koichi Tan-No

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引用次数: 0

Abstract

Marine microalgae, such as Pavlova spp., are known to produce bioactive compounds and have been extensively studied as natural resources with anti-inflammatory properties. Among several Pavlova spp., OPMS 30543 (Pav) has recently been found to contain a high fucoxanthin content. In this study, we aimed to evaluate the effects of Pav treatment on hyperalgesia using a mouse model of adjuvant-induced arthritis (AIA), which was established by injecting complete Freund's adjuvant (CFA). Pav alone did not suppress the hyperalgesia observed in AIA mice. However, combined with low-dose diclofenac (DFC; 0.1 mg/kg) resulted in marked analgesia. In AIA mice, the activation of excitatory neurons was observed in the spinal cord; however, this activation was suppressed by the combination of Pav and DFC. These findings suggest that Pav enhances the analgesic effect of DFC in a mouse arthritis-associated hyperalgesia, and may aid in the development of improved strategies for inflammatory pain management.

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来源期刊

Bioscience, Biotechnology, and Biochemistry 生物-生化与分子生物学

CiteScore

3.50

自引率

0.00%

发文量

183

审稿时长

1 months

期刊介绍： Bioscience, Biotechnology, and Biochemistry publishes high-quality papers providing chemical and biological analyses of vital phenomena exhibited by animals, plants, and microorganisms, the chemical structures and functions of their products, and related matters. The Journal plays a major role in communicating to a global audience outstanding basic and applied research in all fields subsumed by the Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA).