[Artículo traducido] Revisión sistemática sobre suplementos dietéticos en la prevención y/o tratamiento de la queratosis actínica y el campo de cancerización

IF 3.8 Q1 DERMATOLOGY

Actas dermo-sifiliograficas Pub Date : 2025-06-01 DOI:10.1016/j.ad.2025.04.001

A. Rodríguez-Luna , A. Zamarrón , C. Longo , G. Pellacani , K. Peris , P. Calzavara-Pinton , M.V. de Galvez , Y. Gilaberte , M. de Troya , Á. Juarranz , S. González

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引用次数: 0

Abstract

Background

Actinic keratoses (AKs) are chronic, recurrent precancerous lesions primarily induced by long-term sun exposure, commonly found on sun-exposed areas such as the face, neck, hands, forearms, and lower legs. AKs are prevalent, affecting millions worldwide, and pose a significant risk of transforming into invasive squamous cell carcinomas (SCCs).

Objective

This systematic review aims to update the scientific evidence on the role of oral bioactives, nutraceuticals, or dietary supplements in the treatment of AKs and field cancerization, while evaluating their safety and efficacy profile.

Methods

A review plan was pre-registered in the PROSPERO database (CRD42023485985). Following the PRISMA guidelines, we identified, selected, and included relevant studies. We screened a total of 234 articles, thoroughly reviewed 38 full texts, and ultimately included 21 articles published from 2013 through 2023 for analysis.

Results

The selected studies were categorized into three groups based on the chemical nature of the supplements: polyphenols (11 studies), vitamins (8 studies), and others (2 studies). The studies included preclinical (9) and clinical (12) studies. Clinical trials have demonstrated the efficacy profile of polyphenolic supplements, such as Polypodium leucotomos extract (PLE) and others in improving skin health and reducing the risk of skin cancers. Preclinical studies highlighted the protective effects of polyphenols against UV-induced damage and neoplastic transformation. Vitamin supplementation studies revealed mixed results, with clear data showing benefits in reducing the risk of precancerous lesions and skin cancers after nicotinamide (NAM) treatment, while others did not demonstrate significant protective effects.

Conclusions

The review confirms the efficacy of polyphenols in preventing and treating AKs and related skin conditions. However, the role of vitamins and other supplements requires further investigation due to inconsistent and/or scarce findings. Future clinical trials should focus on diverse populations at higher risk of skin cancer and explore new ingredients as well as combinations of various ingredients to optimize therapeutic applications.

Abstract Image

查看原文本刊更多论文

膳食补充剂在预防和/或治疗光化性角化病和野地癌变中的系统评价。

背景：光化性角化病（AKs）是一种慢性、复发性癌前病变，主要由长期阳光照射引起，常见于暴露在阳光下的部位，如面部、颈部、手部、前臂和小腿。AKs普遍存在，影响着全球数百万人，并具有转化为侵袭性鳞状细胞癌（SCCs）的重大风险。目的：本系统综述旨在更新口服生物活性物质、营养保健品或膳食补充剂在治疗AKs和野区癌中的作用的科学证据，同时评估其安全性和有效性。方法：在PROSPERO数据库（CRD42023485985）中预先注册一份综述计划。按照PRISMA指南，我们确定、选择并纳入了相关研究。我们共筛选了234篇文章，彻底审查了38篇全文，最终纳入了2013年至2023年发表的21篇文章进行分析。结果：选定的研究根据补充剂的化学性质分为三组：多酚（11项研究），维生素（8项研究）和其他（2项研究）。这些研究包括临床前(9)和临床（12）研究。临床试验已经证明了多酚类补充剂的功效，如多酚提取物（PLE）和其他多酚类补充剂在改善皮肤健康和降低皮肤癌风险方面的功效。临床前研究强调了多酚对紫外线诱导的损伤和肿瘤转化的保护作用。维生素补充剂研究的结果喜忧参半，有明确的数据显示，在烟酰胺（NAM）治疗后，维生素补充剂有利于降低癌前病变和皮肤癌的风险，而其他研究则没有显示出显著的保护作用。结论：本综述证实了多酚在预防和治疗AKs及相关皮肤疾病中的作用。然而，维生素和其他补充剂的作用需要进一步研究，因为研究结果不一致或很少。未来的临床试验应关注不同的皮肤癌高风险人群，探索新的成分以及各种成分的组合，以优化治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Actas dermo-sifiliograficas DERMATOLOGY-

CiteScore

1.90

自引率

9.40%

发文量

473

审稿时长

56 weeks

期刊介绍： Actas Dermo-Sifiliográficas, publicación Oficial de la Academia Española de Dermatología y Venereología, es una revista de prestigio consolidado. Creada en 1909, es la revista mensual más antigua editada en España.En 2006 entró en Medline, y hoy resulta imprescindible para estar al día sobre la dermatología española y mundial.