Diagnostic value of combining ultrafast cine MRI and morphological measurements on gastroesophageal reflux disease

IF 2.2 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Qing Liu, Yujing Xin, Chao Wu, Jing Li, Hongyan Song, Yihong Zhang, Jie Fu, Zhi Jia, Haoran Sun
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引用次数: 0

Abstract

Purpose

To evaluate the diagnostic performance of combining ultrafast real-time cine MRI with morphological measurements on gastroesophageal reflux disease (GERD).

Methods

In the prospective study, 40 healthy volunteers and 30 GERD patients underwent real-time cine MRI using an undersampled low-angle gradient echo sequence (50 ms/frame) with deep-learning reconstruction, to monitor the gastroesophageal junction (GEJ) and observe the reflux of the contrast agent during the Valsalva maneuver. The width of the lower esophagus, the length of the lower esophageal sphincter (LES), the end-expiratory and post Valsalva maneuver His angle were measured.

Results

There were no statistical differences between the two group either in lower esophageal width (14.06 ± 1.50 mm vs. 14.75 ± 1.57 mm, P > 0.05) or LES length (25.20 ± 1.46 mm vs. 24.39 ± 1.68 mm, P > 0.05). The end-expiratory His angle (84.45 ± 18.67°) and post Valsalva maneuver His angle (101.53 ± 19.22°), and the differences between them (17.08 ± 5.65°) in the GERD group were greater than those in the healthy volunteers (71.51 ± 18.01°, 86.09 ± 18.24°, 14.57 ± 3.88° respectively, P < 0.05). Reflux was induced in 8 cases of GERD group including 4 cases with hiatus hernia and not observed in healthy volunteers. The AUC for diagnosing GERD were 0.702, 0.737 and 0.634 for end-expiratory, post Valsalva maneuver His angle and their differences, when combined with real-time MRI was 0.823, with a sensitivity of 86.67% and a specificity of 67.50%.

Conclusion

Real-time MRI can display dynamic swallowing and reflux at the GEJ. The His angle can serve as a morphological indicator for diagnosing GERD with MRI.

Graphical Abstract

Abstract Image

Abstract Image

超快电影MRI结合形态学检查对胃食管反流病的诊断价值。
目的:评估超快实时电影磁共振成像与胃食管反流病(GERD)形态学测量相结合的诊断性能:在这项前瞻性研究中,40 名健康志愿者和 30 名胃食管反流病患者接受了使用深度学习重建的欠采样低角度梯度回波序列(50 毫秒/帧)的实时 cine MRI 检查,以监测胃食管交界处(GEJ)并观察 Valsalva 动作时造影剂的反流情况。测量了食管下段的宽度、食管下段括约肌(LES)的长度、呼气末和 Valsalva 动作后的 His 角:两组患者的食管下段宽度(14.06 ± 1.50 mm vs. 14.75 ± 1.57 mm,P > 0.05)和 LES 长度(25.20 ± 1.46 mm vs. 24.39 ± 1.68 mm,P > 0.05)均无统计学差异。胃食管反流患者组的呼气末 His 角(84.45 ± 18.67°)和 Valsalva 动作后 His 角(101.53 ± 19.22°)以及它们之间的差异(17.08 ± 5.65°)均大于健康志愿者组(分别为 71.51 ± 18.01°、86.09 ± 18.24°、14.57 ± 3.88°,P 结论:实时磁共振成像可显示动态吞咽和胃食管返流情况。His 角可以作为 MRI 诊断胃食管反流病的形态学指标。
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来源期刊
Abdominal Radiology
Abdominal Radiology Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
5.20
自引率
8.30%
发文量
334
期刊介绍: Abdominal Radiology seeks to meet the professional needs of the abdominal radiologist by publishing clinically pertinent original, review and practice related articles on the gastrointestinal and genitourinary tracts and abdominal interventional and radiologic procedures. Case reports are generally not accepted unless they are the first report of a new disease or condition, or part of a special solicited section. Reasons to Publish Your Article in Abdominal Radiology: · Official journal of the Society of Abdominal Radiology (SAR) · Published in Cooperation with: European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Urogenital Radiology (ESUR) Asian Society of Abdominal Radiology (ASAR) · Efficient handling and Expeditious review · Author feedback is provided in a mentoring style · Global readership · Readers can earn CME credits
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