In Vitro Evaluation of Liposomal Amphotericin B Adsorption With Different Hemofilters for Continuous Hemofiltration.

IF 2.2 3区医学 Q3 ENGINEERING, BIOMEDICAL

Artificial organs Pub Date : 2025-04-04 DOI:10.1111/aor.14980

Toshihisa Hiraiwa, Naohide Kuriyama, Kazuhiro Moriyama, Shigeki Yamada, Tomoyuki Nakamura, Osamu Nishida

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引用次数: 0

Abstract

Background: Fungemia is an infectious disease with a poor prognosis. Continuous hemofiltration (CHF) is widely used for the treatment of acute kidney injury associated with fungemia. However, the effect of hemofiltration membranes for CHF on antifungal drug concentrations remains poorly understood. Therefore, clarifying the adsorption of antifungal drugs onto these membranes is important. We investigated the adsorption properties of liposomal amphotericin B on different hemofiltration membranes using closed-circulation hemofiltration.

Methods: We performed hemofiltration with each solution adjusted to liposomal amphotericin B as a closed circulatory circuit using polyacrylonitrile (AN69ST), polymethyl methacrylate (PMMA), and polysulfone (PS) membranes. Only this circuit was used as a control. Amphotericin B concentration at the inlet and in the effluent of the hemofiltration membrane was measured. The adsorption rate (Ra) of amphotericin B was then calculated.

Results: The concentration of amphotericin B decreased in the PS membranes compared to that in the controls after 15 min (p = 0.03). The Ra of amphotericin B was higher in PS membranes than in the controls (p = 0.02). Amphotericin B was not adsorbed onto the PMMA or AN69ST membranes. The concentration of amphotericin B in these membranes showed no change compared with that in the control after 1440 min. Liposomal amphotericin B was temporarily absorbed on PS membranes, but at clinical doses, it did not appear to affect the antifungal doses.

Conclusions: Different blood purification membranes can be used to treat CHF without affecting the administration of antifungal drugs.

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连续血液滤过剂对两性霉素B脂质体吸附的体外评价。

背景：真菌病是一种预后不良的感染性疾病。持续血液滤过（CHF）被广泛用于治疗急性肾损伤合并真菌血症。然而，CHF血液滤过膜对抗真菌药物浓度的影响仍然知之甚少。因此，澄清抗真菌药物在这些膜上的吸附是很重要的。研究了两性霉素B脂质体在不同血液滤过膜上的吸附特性。方法：我们使用聚丙烯腈（AN69ST）、聚甲基丙烯酸甲酯（PMMA）和聚砜（PS）膜，将每种溶液调整为两性霉素脂质体B作为封闭循环循环进行血液过滤。只有这个电路被用作控制。测定血液滤膜入口和流出处两性霉素B的浓度。然后计算两性霉素B的吸附率（Ra）。结果：15min后，两性霉素B在PS膜中的浓度较对照组降低（p = 0.03）。两性霉素B在PS膜中的Ra含量高于对照组（p = 0.02）。两性霉素B不吸附在PMMA或AN69ST膜上。1440min后，这些膜中两性霉素B的浓度与对照组相比没有变化。脂质体两性霉素B暂时被PS膜吸收，但在临床剂量下，它似乎不影响抗真菌剂量。结论：不同血液净化膜可用于治疗慢性心力衰竭，且不影响抗真菌药物的使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Artificial organs 工程技术-工程：生物医学

CiteScore

4.30

自引率

12.50%

发文量

303

审稿时长

4-8 weeks

期刊介绍： Artificial Organs is the official peer reviewed journal of The International Federation for Artificial Organs (Members of the Federation are: The American Society for Artificial Internal Organs, The European Society for Artificial Organs, and The Japanese Society for Artificial Organs), The International Faculty for Artificial Organs, the International Society for Rotary Blood Pumps, The International Society for Pediatric Mechanical Cardiopulmonary Support, and the Vienna International Workshop on Functional Electrical Stimulation. Artificial Organs publishes original research articles dealing with developments in artificial organs applications and treatment modalities and their clinical applications worldwide. Membership in the Societies listed above is not a prerequisite for publication. Articles are published without charge to the author except for color figures and excess page charges as noted.