Quantification of perforant path fibers for early detection of Alzheimer's disease

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-04-06 DOI:10.1002/alz.70142

Yuto Uchida, Zhipeng Hou, Laura Gomez-Isaza, Maria Luongo, Juan C. Troncoso, Michael I. Miller, Susumu Mori, Kenichi Oishi

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引用次数: 0

Abstract

INTRODUCTION

The entorhinal cortex (ERC) and perforant path (PP) fibers are critical structures in the pathology of Alzheimer's disease (AD). This study aims to explore these regions using high-field magnetic resonance imaging (MRI), with the goal of identifying reliable biomarkers based on histopathological observations.

METHODS

Twenty post mortem brain specimens were scanned with 11.7T MRI, including diffusion tensor imaging and tractography, and were cut for subsequent histological examinations. The entorhinal cortical thickness and number of PP fibers derived from MRI were compared across neuropathological and premortem clinical diagnoses of AD.

RESULTS

The entorhinal cortical thickness and number of PP fibers decreased along with severities of neurofibrillary tangles in the ERC. Meanwhile, a reduction in the number of PP fibers, but not the entorhinal cortical thickness, was observed during the preclinical stage of AD.

CONCLUSIONS

Degeneration of PP fibers was observed in early AD and progressed along with neuropathological changes.

Highlights

Twenty post mortem brain tissues were scanned with 11.7T MRI.
Degeneration of PP fibers was observed at 250 µm isotropic resolution.
PP fiber indices were linked with severities of NFTs.
The number of PP fibers was decreased in preclinical AD.

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定量穿孔路径纤维对阿尔茨海默病的早期检测

内嗅皮层（ERC）和穿孔通路（PP）纤维是阿尔茨海默病（AD）病理中的关键结构。本研究旨在利用高场磁共振成像（MRI）探索这些区域，目的是根据组织病理学观察确定可靠的生物标志物。方法对20例死后脑标本进行11.7T MRI扫描，包括弥散张量成像和神经束造影，并切开进行后续组织学检查。通过神经病理学和死前临床诊断，比较了MRI显示的嗅内皮层厚度和PP纤维数量。结果随着ERC中神经原纤维缠结的严重程度，内嗅皮层厚度和PP纤维数量减少。同时，在阿尔茨海默病的临床前阶段，观察到PP纤维数量减少，但未观察到嗅内皮层厚度减少。结论阿尔茨海默病早期可见PP纤维变性，并随神经病理改变而进展。对20例死后脑组织进行11.7T MRI扫描。在250µm各向同性分辨率下观察PP纤维的变性。PP纤维指数与nft的严重程度有关。临床前AD患者PP纤维数量减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.