Interpenetrating Polymer Network Hydrogels with Tunable Viscoelasticity and Proteolytic Cleavability to Direct Stem Cells In Vitro (Adv. Healthcare Mater. 9/2025)

IF 10 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-04-07 DOI:10.1002/adhm.202570055

Prannoy Seth, Jens Friedrichs, Yanuar Dwi Putra Limasale, Nicole Fertala, Uwe Freudenberg, Yixin Zhang, Ayala Lampel, Carsten Werner

引用次数: 0

Abstract

Viscoelastic sGAG-Hydrogels

In article 2402656, Carsten Werner and co-workers introduce a sulfated glycosaminoglycan (sGAG)-based interpenetrating polymer network hydrogel platform with tunable viscoelasticity, stiffness, and proteolytic cleavability. This platform enables the detailed study of stem cell morphogenesis, showing improved cell spreading and YAP activation in human mesenchymal stem cells, and modified morphogenesis in human induced pluripotent stem cell cysts.

Abstract Image

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粘弹性 sGAG 水凝胶在第 2402656 号文章中，Carsten Werner 及其合作者介绍了一种基于硫酸化氨基糖（sGAG）的互穿聚合物网络水凝胶平台，它具有可调的粘弹性、硬度和蛋白水解可裂解性。该平台可对干细胞的形态发生进行详细研究，显示人类间充质干细胞的细胞铺展和YAP激活得到改善，人类诱导多能干细胞囊肿的形态发生得到改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.