Current Advancements in Serum Protein Biomarkers for Hepatitis B Virus-Associated Hepatocyte Remodeling and Hepatocellular Carcinoma

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2025-04-07 DOI:10.1002/iid3.70171

Adane Adugna, Gashaw Azanaw Amare, Mohammed Jemal

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Abstract

Background

Hepatitis B virus (HBV)-related liver cancer is the third most common cause of cancer-related death globally. Hepatocyte remodeling, also known as hepatocyte transformation and immortalization, and hepatocellular carcinoma (HCC), are brought on by persistent inflammation caused by HBV in the host hepatocytes. One of the main concerns in the perspective of HBV-induced hepatocyte remodeling and liver cancer is accurately identifying cancer stages to maximize early screening and detection. Biological signatures have a significant impact on solving this problem.

Objective

This review article aimed to discuss the novel serum protein biomarkers for HBV-induced hepatocyte remodeling and HCC.

Methods

The information was collected from various peer-reviewed journals through electronic searches utilizing various search engines, including PubMed, Google Scholar, HINARI, and Cochrane Library from 2017 to 2024. Keywords for searches included “serum protein biomarkers in HBV-HCC,” “blood-based biomarkers in HBV-HCC,” and “viral biomarkers for HBV-HCC.”

Results

Recently, novel protein signatures have been discovered for the early diagnosis, treatment, and prognosis of HBV-induced hepatic cell remodeling and HCC from proteomic data sets. We have discussed the recent literature on the clinical utility of the protein signatures for the diagnosis and forecasting of HBV-associated hepatocyte remodeling and HCC, including golgi protein 73 (GP73), glypican-3 (GPC3), midkine (MDK), des-γ-carboxy-prothrombin (DCP), von Willebrand factor (vWF), pentraxin 3 (PTX3), pseudouridine synthases 7 (PUSs 7), squamous cell carcinoma antigen (SCCA), and osteopontin (OPN).

Conclusion

All these protein markers also exhibit the survival of HBV-related HCC patients, the proliferation, migration, antiapoptosis, mitogenesis, transformation, and angiogenesis of HBV-infected hepatocytes.

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乙型肝炎病毒相关肝细胞重塑和肝细胞癌血清蛋白生物标志物研究进展

背景与乙型肝炎病毒（HBV）相关的肝癌是全球癌症相关死亡的第三大常见原因。肝细胞重塑（又称肝细胞转化和永生化）和肝细胞癌（HCC）是由宿主肝细胞中的 HBV 引起的持续炎症导致的。从 HBV 引起的肝细胞重塑和肝癌的角度来看，人们关注的主要问题之一是准确识别癌症阶段，以最大限度地进行早期筛查和检测。生物特征对解决这一问题具有重要影响。目的本文旨在讨论 HBV 诱导的肝细胞重塑和 HCC 的新型血清蛋白生物标志物。方法通过使用各种搜索引擎（包括 PubMed、Google Scholar、HINARI 和 Cochrane Library）进行电子检索，从 2017 年至 2024 年期间的各种同行评审期刊中收集信息。搜索关键词包括 "HBV-HCC 中的血清蛋白生物标志物"、"HBV-HCC 中基于血液的生物标志物 "和 "HBV-HCC 的病毒生物标志物"。结果最近，人们从蛋白质组数据集中发现了新的蛋白质特征，这些特征可用于 HBV 引起的肝细胞重塑和 HCC 的早期诊断、治疗和预后。我们讨论了最近关于这些蛋白质特征对诊断和预测 HBV 相关肝细胞重塑和 HCC 的临床实用性的文献，其中包括高尔基体蛋白 73 (GP73)、GP73、glypican-3 (GPC3)、midkine (MDK)、des-γ-carboxy-prothrombin (DCP)、von Willebrand factor (vWF)、pentraxin 3 (PTX3)、pseudouridine synthases 7 (PUSs 7)、鳞状细胞癌抗原 (SCCA) 和 osteopontin (OPN)。结论所有这些蛋白标记物还显示了与 HBV 相关的 HCC 患者的存活率、HBV 感染肝细胞的增殖、迁移、抗凋亡、有丝分裂、转化和血管生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology