Inequalities in Fertility-Impacting Cancer Incidence Among Young Populations in the United States

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-04-06 DOI:10.1002/cam4.70797

Katherine I. Tierney, Jennifer Therrien, Stephanie Ellwood, Lisa Graves

{"title":"Inequalities in Fertility-Impacting Cancer Incidence Among Young Populations in the United States","authors":"Katherine I. Tierney, Jennifer Therrien, Stephanie Ellwood, Lisa Graves","doi":"10.1002/cam4.70797","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>Infertility is a concerning late effect of cancer and cancer treatments, yet referrals for fertility preservation are unequal across U.S. sociodemographic groups. Although all-site cancer incidence varies across U.S. sociodemographic groups, it is unclear whether fertility-impacting cancers, specifically, are unevenly distributed by sex or race/ethnicity.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Cross-sectional analysis of cancer registry data from the Surveillance, Epidemiology, and End Results (SEER) Program (2010–2020). Age-specific demographic rates and negative binomial regression with an exposure for population size were employed to assess inequalities in the incidence rates of fertility-impacting cancers among U.S. individuals aged 39 and younger. Wald tests were used to compare coefficients across the multivariable negative binomial regression models.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Women had higher incidence rates of fertility-impacting cancers (cancers of the reproductive organs, cancers in areas proximal to the reproductive organs or that contribute to reproductive functioning, and other cancers identified in the literature as fertility-impacting) in the fully adjusted models. These associations differed from the patterns observed among all other types of cancers. The incidence rates of fertility-impacting cancers also varied by race/ethnic groups. However, the patterning observed by race-ethnicity varied between the three fertility-impacting cancer groups.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The burden of fertility-impacting cancers is unequal across sex and race/ethnic groups. The sociodemographic patterns observed in fertility-impacting cancers differ substantively from cancers that were not identified as fertility-impacting. The findings reinforce the importance of screening for fertility-impacting cancers and identify a potential unmet need for both fertility preservation referrals among cancer patients and access to fertility treatment for survivors of cancer.</p>\n </section>\n </div>","PeriodicalId":139,"journal":{"name":"Cancer Medicine","volume":"14 7","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cam4.70797","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Medicine","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cam4.70797","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Infertility is a concerning late effect of cancer and cancer treatments, yet referrals for fertility preservation are unequal across U.S. sociodemographic groups. Although all-site cancer incidence varies across U.S. sociodemographic groups, it is unclear whether fertility-impacting cancers, specifically, are unevenly distributed by sex or race/ethnicity.

Methods

Cross-sectional analysis of cancer registry data from the Surveillance, Epidemiology, and End Results (SEER) Program (2010–2020). Age-specific demographic rates and negative binomial regression with an exposure for population size were employed to assess inequalities in the incidence rates of fertility-impacting cancers among U.S. individuals aged 39 and younger. Wald tests were used to compare coefficients across the multivariable negative binomial regression models.

Results

Women had higher incidence rates of fertility-impacting cancers (cancers of the reproductive organs, cancers in areas proximal to the reproductive organs or that contribute to reproductive functioning, and other cancers identified in the literature as fertility-impacting) in the fully adjusted models. These associations differed from the patterns observed among all other types of cancers. The incidence rates of fertility-impacting cancers also varied by race/ethnic groups. However, the patterning observed by race-ethnicity varied between the three fertility-impacting cancer groups.

Conclusion

The burden of fertility-impacting cancers is unequal across sex and race/ethnic groups. The sociodemographic patterns observed in fertility-impacting cancers differ substantively from cancers that were not identified as fertility-impacting. The findings reinforce the importance of screening for fertility-impacting cancers and identify a potential unmet need for both fertility preservation referrals among cancer patients and access to fertility treatment for survivors of cancer.

Abstract Image

查看原文本刊更多论文

美国年轻人口中生育率影响癌症发病率的不平等

不孕不育是癌症和癌症治疗的晚期影响，但在美国的社会人口群体中，保留生育能力的转诊是不平等的。尽管美国不同社会人口群体的全部位癌症发病率不同，但目前尚不清楚影响生育的癌症是否在性别或种族/民族方面分布不均。方法对来自监测、流行病学和最终结果（SEER）项目（2010-2020）的癌症登记数据进行横断面分析。采用特定年龄人口统计率和人口规模暴露的负二项回归来评估美国39岁及以下人群中影响生育的癌症发病率的不平等。使用Wald检验比较多变量负二项回归模型的系数。结果在完全调整后的模型中，女性患影响生育的癌症（生殖器官癌症、生殖器官近端癌症或影响生殖功能的癌症，以及文献中确定的其他影响生育的癌症）的发病率更高。这些关联不同于在所有其他类型的癌症中观察到的模式。影响生育的癌症发病率也因种族/族裔群体而异。然而，在三个影响生育能力的癌症组中，观察到的种族模式有所不同。结论影响生育的癌症的负担在性别和种族/民族之间是不平等的。在影响生育的癌症中观察到的社会人口模式与未确定为影响生育的癌症有很大不同。研究结果强调了筛查影响生育的癌症的重要性，并确定了癌症患者保留生育能力转诊和癌症幸存者获得生育治疗的潜在未满足需求。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.