Lifestyle-Related Risk Factors for Pancreatic Ductal Adenocarcinoma: A Longitudinal Analysis of 1,120,377 Individuals From the NHISS Cohort

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-04-06 DOI:10.1002/cam4.70848

Hyunseok Jee

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Abstract

Objective

Utilizing data from the National Health Insurance Sharing Service database, this study explored significant risk factors for pancreatic cancer in a cohort of 1,120,377 South Korean individuals over a 10-year period (2009–2019).

Methods

Propensity score matching was employed to ensure comparability between 3535 pancreatic cancer patients and a control group with a common cold diagnosis. The study analyzed various lifestyle factors and biochemical markers, including smoking status, alcohol consumption, fasting blood glucose (FBS) levels, liver enzyme levels, and Charlson comorbidity index (CCI) scores.

Results

The findings revealed that current smoking, frequent alcohol consumption, and elevated levels of FBS and liver enzymes were associated with an increased risk of pancreatic cancer. Conversely, engaging in high-intensity exercise (≥ 20 min, twice weekly) was correlated with a 20% reduction in pancreatic cancer risk (p < 0.05). Additionally, optimal thresholds for total cholesterol (179.50 mg/dL), GGT (29.50 U/L), low-density lipoprotein cholesterol (104.50 mg/dL), and CCI score (2.50) were identified, which may facilitate early diagnosis and intervention.

Conclusions

These findings underscore the importance of modifiable lifestyle factors in managing pancreatic cancer risk and highlight the potential of personalized, evidence-based interventions—such as high-intensity exercise programs—in improving prevention and treatment outcomes.

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生活方式相关的胰腺导管腺癌危险因素：来自niss队列的1,120,377人的纵向分析

目的本研究利用国民健康保险共享服务数据库的数据，探讨了韩国 1,120,377 人队列中 10 年间（2009-2019 年）胰腺癌的重要风险因素。方法采用倾向得分匹配法，以确保 3535 名胰腺癌患者与诊断为普通感冒的对照组之间的可比性。研究分析了各种生活方式因素和生化指标，包括吸烟状况、饮酒量、空腹血糖（FBS）水平、肝酶水平和查尔森合并症指数（CCI）评分。结果研究结果显示，目前吸烟、经常饮酒、空腹血糖和肝酶水平升高与胰腺癌风险增加有关。相反，从事高强度运动（≥ 20 分钟，每周两次）与胰腺癌风险降低 20% 相关（p < 0.05）。此外，还确定了总胆固醇（179.50 mg/dL）、谷草转氨酶（29.50 U/L）、低密度脂蛋白胆固醇（104.50 mg/dL）和 CCI 评分（2.50）的最佳阈值，这可能有助于早期诊断和干预。结论这些发现强调了可改变的生活方式因素在控制胰腺癌风险中的重要性，并凸显了个性化的循证干预措施（如高强度运动计划）在改善预防和治疗效果方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.