Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN

IF 3 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Pub Date : 2025-04-06 DOI:10.1111/1753-0407.70068

Jinzhou Liu, Min Guo, Xiaobin Yuan, Xiao Fan, Jin Wang, Xiangying Jiao

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Abstract

Background

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with a complex pathogenesis.

Methods

Recent studies were reviewed to explore the role of gut microbiota and its metabolites in DN development.

Results

Dysbiosis of gut bacteria contributes to pathological changes such as glomerular sclerosis and renal tubule injury. Microbial metabolites are involved in DN through immune and inflammatory pathways.

Conclusions

Understanding the relationship between gut microbiota, its metabolites, and DN may offer potential implications for DN diagnosis, prevention, and treatment. Translating this knowledge into clinical practice presents challenges and opportunities.

Abstract Image

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肠道菌群及其代谢产物：糖尿病肾病的潜在驱动因素？揭示肠道微生物在DN中的作用

背景：糖尿病肾病（DN）是糖尿病的严重微血管并发症，发病机制复杂。方法回顾近年来的研究，探讨肠道菌群及其代谢物在DN发生中的作用。结果肠道菌群失调导致肾小球硬化、肾小管损伤等病理改变。微生物代谢物通过免疫和炎症途径参与DN。结论了解肠道菌群及其代谢物与DN之间的关系可能为DN的诊断、预防和治疗提供潜在的意义。将这些知识转化为临床实践带来了挑战和机遇。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

2.20%

发文量

审稿时长

>12 weeks

期刊介绍： Journal of Diabetes (JDB) devotes itself to diabetes research, therapeutics, and education. It aims to involve researchers and practitioners in a dialogue between East and West via all aspects of epidemiology, etiology, pathogenesis, management, complications and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. The Editorial team is international with a unique mix of Asian and Western participation. The Editors welcome submissions in form of original research articles, images, novel case reports and correspondence, and will solicit reviews, point-counterpoint, commentaries, editorials, news highlights, and educational content.