{"title":"Artificial cells and biomimicry cells: A rising star in the fight against cancer","authors":"Renata Faria Maia, Asma Sadat Vaziri, Mohammad-Ali Shahbazi, Hélder A. Santos","doi":"10.1016/j.mtbio.2025.101723","DOIUrl":null,"url":null,"abstract":"<div><div>Biomimetic Artificial Cells (ACs) are engineered systems that mimic the properties and functions of natural cells, offering significant potential for biomedical applications. The performance and applicability of these synthetic constructs depend on the choice of materials and fabrication methods. Our review delves into the materials, fabrication techniques, and diverse applications of ACs, emphasizing their transformative impact on the field of cancer therapy as smart vehicles for drug delivery, immune system stimulation, cancer cell targeting to minimize off-target effects and maximizing therapeutic efficacy as well as <em>in vitro</em> models for cancer research. By providing a comprehensive overview, we aim to elucidate how these synthetic cells can move the field forward, offering innovative solutions to longstanding challenges in cancer treatment and opening new frontiers in less toxic treatment options.</div></div>","PeriodicalId":18310,"journal":{"name":"Materials Today Bio","volume":"32 ","pages":"Article 101723"},"PeriodicalIF":8.7000,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Today Bio","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2590006425002820","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Biomimetic Artificial Cells (ACs) are engineered systems that mimic the properties and functions of natural cells, offering significant potential for biomedical applications. The performance and applicability of these synthetic constructs depend on the choice of materials and fabrication methods. Our review delves into the materials, fabrication techniques, and diverse applications of ACs, emphasizing their transformative impact on the field of cancer therapy as smart vehicles for drug delivery, immune system stimulation, cancer cell targeting to minimize off-target effects and maximizing therapeutic efficacy as well as in vitro models for cancer research. By providing a comprehensive overview, we aim to elucidate how these synthetic cells can move the field forward, offering innovative solutions to longstanding challenges in cancer treatment and opening new frontiers in less toxic treatment options.
期刊介绍:
Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).