Association between anti-thyroid peroxidase antibody and insufficient sleep in euthyroid population

IF 5.3 1区心理学 Q1 PSYCHOLOGY, CLINICAL

International Journal of Clinical and Health Psychology Pub Date : 2025-04-01 DOI:10.1016/j.ijchp.2025.100565

Yuji Shimizu , Yuko Noguchi , Nagisa Sasaki , Mutsumi Matsuu-Matsuyama , Shin-Ya Kawashiri , Hirotomo Yamanashi , Kazuhiko Arima , Seiko Nakamichi , Yasuhiro Nagata , Naomi Hayashida , Takahiro Maeda

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引用次数: 0

Abstract

Background

Low sleep quality induces inflammation. Because anti-thyroid peroxidase antibody (TPO-Ab) is an autoantibody that induces inflammation in the thyroid, insufficient sleep may stimulate the production of TPO-Ab. However, the thyroid function is also associated with sleep. Therefore, to evaluate the association between TPO-Ab positivity and insufficient sleep, the target population should be limited to euthyroid individuals whose free triiodothyronine (T3), free thyroxine (T4), and thyroid-stimulating hormone (TSH) are within the normal ranges.

Method

This cross-sectional study recruited 1324 euthyroid individuals who participated in annual health checkups. Insufficient sleep was assessed by using a questionnaire. Individuals with free T3, free T4, and TSH levels within the normal ranges were defined as euthyroid.

Results

Among the study population, 406 had insufficient sleep, and 242 were TPO-Ab-positive. Insufficient sleep was associated with a higher likelihood of TPO-Ab positivity. Sex and age adjusted odd ratios (95 % confidence intervals, p) of TPO-Ab positive for insufficient sleep was 1.47 (1.08, 2.01, p = 0.014). These associations remained unchanged even after further adjustment for free T4 and TSH, status of body mass index, smoking status, drinking status, mental distress, and physical activity; 1.53 (1.11, 2.10, p = 0.009).

Conclusion

Euthyroid individuals with insufficient sleep may be at risk of autoimmune thyroiditis. Although further investigations are necessary, sleep disorder therapy might reduce the risk of the incidence of autoimmune thyroiditis.

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甲状腺功能正常人群抗甲状腺过氧化物酶抗体与睡眠不足的关系

低睡眠质量会诱发炎症。由于抗甲状腺过氧化物酶抗体（TPO-Ab）是一种诱导甲状腺炎症的自身抗体，睡眠不足可能会刺激TPO-Ab的产生。然而，甲状腺功能也与睡眠有关。因此，为了评估TPO-Ab阳性与睡眠不足之间的关系，目标人群应限于游离三碘甲状腺原氨酸（T3）、游离甲状腺素（T4）和促甲状腺激素（TSH）在正常范围内的甲状腺功能正常的个体。方法本横断面研究招募1324名参加年度健康检查的甲状腺功能正常的个体。通过问卷调查来评估睡眠不足。游离T3、游离T4和TSH水平在正常范围内的个体被定义为甲状腺功能正常。结果406例睡眠不足，242例tpo - ab阳性。睡眠不足与TPO-Ab阳性的可能性较高有关。睡眠不足患者TPO-Ab阳性的性别和年龄校正奇数比（95%可信区间，p）为1.47 （1.08,2.01,p = 0.014）。即使在进一步调整游离T4和TSH、体重指数、吸烟状况、饮酒状况、精神困扰和身体活动状况后，这些关联仍未改变；1.53 （1.11, 2.10, p = 0.009）。结论睡眠不足的甲状腺功能正常者有发生自身免疫性甲状腺炎的危险。虽然需要进一步的研究，但睡眠障碍治疗可能会降低自身免疫性甲状腺炎的发病率。

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来源期刊

International Journal of Clinical and Health Psychology PSYCHOLOGY, CLINICAL-

CiteScore

10.70

自引率

5.70%

发文量

审稿时长

33 days

期刊介绍： The International Journal of Clinical and Health Psychology is dedicated to publishing manuscripts with a strong emphasis on both basic and applied research, encompassing experimental, clinical, and theoretical contributions that advance the fields of Clinical and Health Psychology. With a focus on four core domains—clinical psychology and psychotherapy, psychopathology, health psychology, and clinical neurosciences—the IJCHP seeks to provide a comprehensive platform for scholarly discourse and innovation. The journal accepts Original Articles (empirical studies) and Review Articles. Manuscripts submitted to IJCHP should be original and not previously published or under consideration elsewhere. All signing authors must unanimously agree on the submitted version of the manuscript. By submitting their work, authors agree to transfer their copyrights to the Journal for the duration of the editorial process.