Gold nanoparticle-enabled doxorubicin delivery: Advancing targeted chemotherapy in cancer therapy

IF 4.4 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Communications Pub Date : 2025-04-04 DOI:10.1016/j.inoche.2025.114467

Rishabh Aggarwal , Amaan Ahmed , B.H. Jaswanth Gowda , Garima Gupta , Nazim Nasir , Shadma Wahab , Afsana Sheikh , Prashant Kesharwani

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Abstract

Gold nanoparticles are considered one of the safest metallic nanocarriers for delivering drugs to cancerous tumors. This approach signifies a pioneering advancement in cancer therapy owing to the multifaceted attributes exhibited by these nanoparticles. These attributes encompass photothermal effects, radiotherapeutic potentials, imaging enhancements, diagnostic functionalities, and proficient drug delivery vehicles. This review offers concise insights into doxorubicin, elucidating its mechanism of action, and associated adverse effects. Additionally, it provides a brief overview of gold nanoparticles, highlighting their optical and magnetic properties, as well as their capacity for both active and passive targeted drug delivery. Furthermore, the review provides an in-depth examination of gold nanoparticle-mediated doxorubicin delivery for the treatment of various cancer types, including its toxicity profile and related patents.

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金纳米颗粒使阿霉素递送：推进癌症治疗的靶向化疗

金纳米粒子被认为是最安全的金属纳米载体之一，用于向癌症肿瘤输送药物。由于这些纳米颗粒具有多方面的特性，这种方法标志着癌症治疗的开创性进步。这些属性包括光热效应、放射治疗潜力、成像增强、诊断功能和熟练的药物输送载体。这篇综述提供了关于阿霉素的简明见解，阐明了它的作用机制和相关的不良反应。此外，它还提供了金纳米粒子的简要概述，重点介绍了它们的光学和磁性，以及它们的主动和被动靶向药物递送能力。此外，该综述还深入研究了金纳米颗粒介导的阿霉素递送治疗各种癌症类型，包括其毒性概况和相关专利。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inorganic Chemistry Communications 化学-无机化学与核化学

CiteScore

5.50

自引率

7.90%

发文量

1013

审稿时长

53 days

期刊介绍： Launched in January 1998, Inorganic Chemistry Communications is an international journal dedicated to the rapid publication of short communications in the major areas of inorganic, organometallic and supramolecular chemistry. Topics include synthetic and reaction chemistry, kinetics and mechanisms of reactions, bioinorganic chemistry, photochemistry and the use of metal and organometallic compounds in stoichiometric and catalytic synthesis or organic compounds.