Structural, optical, and antioxidant properties of biocompatible CuO-MgO nanocomposites

Results in Materials Pub Date : 2025-04-03 DOI:10.1016/j.rinma.2025.100695

B.V. Vamsi Krishna , B. Durga Lakshmi , P. Tirupathi Rao , R.K. Ramachandra

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Abstract

This study synthesized a CuO-MgO nanocomposite using Tinospora cordifolia (TC) leaf extract through co-precipitation. Characterization using XRD, UV–visible spectroscopy, FTIR, FESEM with EDAX, HRTEM, and DLS-Zeta potential analysis confirmed the formation and properties of the nanocomposite. XRD confirmed the coexistence of CuO and MgO phases. UV–visible spectroscopy showed SPR peaks at 209 nm and 232 nm (MgO), 281.5 nm, and 307 nm (CuO). Indirect and direct band gaps formed within the same nanocomposite were analyzed through the optical conductivity spectrum. FTIR indicated that phenolic and flavonoid groups from the leaf extract acted as capping and reducing agents. FESEM and HRTEM showed spherical morphology, with EDAX confirming the elemental composition. HRTEM micrographs revealed the core-shell structure of TC CuO-MgO NC and SAED bright-spot rings confirming the formation of two phases in the prepared nanocomposite. The average particle size was 49.129 ± 1.2622 nm through HRTEM findings, and DLS-Zeta potential analysis showed a size of 63.266 nm, polydispersity index of 0.137, and zeta potential of −22.8 mV. The nanocomposite demonstrated a hemolysis percentage of 0.5708 ± 0.0016 % at 100 μg/ml, indicating biocompatibility. Its IC₅₀ value for antioxidant activity was 20.8919 μg/ml, close to that of ascorbic acid. These findings suggest that TC CuO-MgO nanocomposite is suitable for optoelectronic, photodynamic therapy, and biomedical applications.

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生物相容性CuO-MgO纳米复合材料的结构、光学和抗氧化性能

本研究以Tinospora cordifolia （TC）叶提取物为原料，通过共沉淀法合成了CuO-MgO纳米复合材料。通过XRD、uv -可见光谱、FTIR、FESEM （EDAX）、HRTEM和DLS-Zeta电位分析等表征手段证实了纳米复合材料的形成和性能。XRD证实了CuO和MgO相的共存。紫外可见光谱显示，MgO的SPR峰位于209 nm和232 nm， CuO的SPR峰位于281.5 nm和307 nm。通过光导谱分析了在同一纳米复合材料内部形成的间接带隙和直接带隙。红外光谱分析表明，叶提取物中的酚类和黄酮类具有封盖和还原作用。FESEM和HRTEM显示为球形形貌，EDAX证实了元素组成。HRTEM显微图像显示了TC、CuO-MgO、NC和SAED亮环的核壳结构，证实了制备的纳米复合材料中形成了两相。HRTEM平均粒径为49.129±1.2622 nm， DLS-Zeta电位分析显示粒径为63.266 nm，多分散性指数为0.137，zeta电位为- 22.8 mV。在100 μg/ml下，该纳米复合材料的溶血率为0.5708±0.0016%，具有良好的生物相容性。其抗氧化活性IC50值为20.8919 μg/ml，与抗坏血酸的IC50值相近。这些发现表明，TC - CuO-MgO纳米复合材料适合于光电子、光动力治疗和生物医学应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Results in Materials

CiteScore

5.30

自引率

0.00%

发文量