Pyrrolopyrrole Cyanine-Based Polymer with Superior Multifunctionality for Boosting Cancer Phototheranostics

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2025-03-19 DOI:10.1021/acsmaterialslett.5c0025910.1021/acsmaterialslett.5c00259

Xue Meng, Yingnan Xu, Yuan Zhang, Huaxin Zhu, Jianwen Song, Ji Qi*, Wenqiang Qiao* and Di Zhang*,

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Abstract

Molecular agents with exceptional multifunctionality are highly sought for phototheranostic applications. Herein we present a high-performance polymer for near-infrared II (NIR-II) fluorescence and photoacoustic (PA) imaging-guided mild photothermal therapy (mPTT) of tumors. We synthesize a series of semiconducting polymers based on pyrrolopyrrole cyanine, identifying that P(P-T) exhibits large mass extinction coefficient (139 L g^–1 cm^–1), excellent photothermal performance, bright NIR-II fluorescence, and PA imaging signals, making it among the highest-performing polymers in these properties. A tumor-targeting agent was developed by coencapsulating the high-performance polymer with a heat shock protein (HSP) inhibitor and camouflaging with M1 macrophage membranes. The integration of NIR-II fluorescence and PA imaging enables comprehensive tumor site delineation, guiding subsequent therapeutic intervention. In 4T1 tumor-bearing mice, the synergistic effect of mPTT under low-power 808 nm laser irradiation, combined with HSP inhibition, resulted in significant tumor suppression. This work offers valuable insights for designing advanced phototheranostic agents.

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具有优越多功能性的吡咯吡咯菁基聚合物促进癌症光疗

具有特殊多功能的分子制剂在光疗应用中备受追捧。在此，我们提出了一种用于近红外II （NIR-II）荧光和光声（PA）成像引导肿瘤轻度光热治疗（mPTT）的高性能聚合物。我们合成了一系列基于吡咯吡咯菁菁的半导体聚合物，发现P（P- t）具有大的质量消光系数（139 L g-1 cm-1），优异的光热性能，明亮的NIR-II荧光和PA成像信号，使其成为这些性能中性能最高的聚合物之一。通过将高性能聚合物与热休克蛋白（HSP）抑制剂共包并伪装在M1巨噬细胞膜上，开发了一种肿瘤靶向剂。NIR-II荧光和PA成像的结合可以全面描绘肿瘤部位，指导后续的治疗干预。在4T1荷瘤小鼠中，mPTT在低功率808 nm激光照射下协同作用，联合HSP抑制作用，产生显著的肿瘤抑制作用。这项工作为设计先进的光治疗药物提供了有价值的见解。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.