Camouflaging Attenuated Salmonella by Detachable Metal Polyphenol Nanoshells for Enhanced Bacteria-Based Cancer Immunotherapy

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2025-03-26 DOI:10.1021/acsmaterialslett.5c0001210.1021/acsmaterialslett.5c00012

Bin Zhang, Rui-Mei Jin, Xiao-Ting Xie, Lin-Fang Tan, Meng-Wen Ma, Chao-Qin Li, Yuan-Di Zhao, Qiong Wang*, Jia-Hua Zou* and Bo Liu*,

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Abstract

We developed Salmonella typhimurium VNP20009 camouflaged biodegradable metal polyphenol nanoshells for efficiently reducing bacterial virulence and prolonging bacterial in vivo circulation time to increase bacterial tumor enrichment. The four-layer nanoshell-encapsulated VNP20009 (M₄@V) ensured the safety of treatment by effectively inhibiting bacterial proliferation and significantly reducing the toxicity in vivo. Moreover, the nanoshells significantly enhanced the biocompatibility of VNP20009 to protect it from phagocytosis, resulting in a 4-fold in vivo circulation time and a 1.97-fold increase in peak accumulation at the tumor sites. After the M₄@V colonized in the tumor microenvironment, physiologically relevant levels of ascorbic acid (AA) triggered the degradation of the nanoshells to restore the proliferation of VNP20009 at the tumor sites. Within 4T1 tumor-bearing mouse models, the AA+M4@V showed remarkable efficacy in suppressing both primary and metastatic tumors and was accompanied by a highly specific immune response.

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可分离的金属多酚纳米壳伪装减毒沙门氏菌用于增强基于细菌的癌症免疫治疗

研制鼠伤寒沙门菌VNP20009伪装可降解金属多酚纳米壳，有效降低细菌毒力，延长细菌体内循环时间，增加细菌肿瘤富集。四层纳米壳封装的VNP20009 （M4@V）通过有效抑制细菌增殖和显著降低体内毒性，确保了治疗的安全性。此外，纳米壳显著增强了VNP20009的生物相容性，保护其免受吞噬，导致体内循环时间延长4倍，肿瘤部位的峰值积累增加1.97倍。M4@V定殖在肿瘤微环境中后，生理相关水平的抗坏血酸（AA）触发纳米壳降解，恢复VNP20009在肿瘤部位的增殖。在4T1荷瘤小鼠模型中，AA+M4@V对原发和转移性肿瘤均表现出显著的抑制作用，并伴有高度特异性的免疫应答。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.