Prenatal exposure to per-and polyfluoroalkyl substances and its association with Developmental Defects of Enamel (DDE) and dental caries in 4 years old children: Findings from Shanghai birth cohort

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-04-01 DOI:10.1016/j.envint.2025.109411

Kaiweisa Abuduxukuer , Huning Wang , Chuchu Wang , Xinyi Luo , Xiaoli Zeng , Dongxin Da , Jin Yu , Wenjian Lu , Jun Zhang , Ying Zhang , Jianfeng Luo , Hao Zhang , for the Shanghai Birth Cohort Study

{"title":"Prenatal exposure to per-and polyfluoroalkyl substances and its association with Developmental Defects of Enamel (DDE) and dental caries in 4 years old children: Findings from Shanghai birth cohort","authors":"Kaiweisa Abuduxukuer , Huning Wang , Chuchu Wang , Xinyi Luo , Xiaoli Zeng , Dongxin Da , Jin Yu , Wenjian Lu , Jun Zhang , Ying Zhang , Jianfeng Luo , Hao Zhang , for the Shanghai Birth Cohort Study","doi":"10.1016/j.envint.2025.109411","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with potential health risks. While the association between PFAS and dental health is under-researched, this study aims to address this gap by investigating prenatal PFAS exposure in relation to Developmental Defects of Enamel (DDE) and dental caries in children.</div></div><div><h3>Methods</h3><div>This study included 1,136 children from the Shanghai Birth Cohort, with maternal blood samples collected during early pregnancy to measure concentrations of 10 PFAS compounds. Oral health outcomes, assessed when the children were 4 years old, included the prevalence of DDE and dental caries, as well as DDE tooth count and the decayed, missing, and filled teeth (dmft) index. Logistic regression and zero-inflated negative binomial regression were used to examine associations between individual PFAS compounds and oral health outcomes. Restricted Cubic Splines (RCS) were used to explore potential nonlinear associations. Additionally, Bayesian Kernel Machine Regression (BKMR), Weighted Quantile Sum (WQS), and Quantile G-Computation (QGC) were employed to assess the joint effects of PFAS mixtures on the outcomes.</div></div><div><h3>Results</h3><div>Individual PFAS compounds, particularly perfluorobutane sulfonate (PFBS) and perfluoroheptanoic acid (PFHpA), exhibited heterogeneous associations with DDE prevalence. PFBS was linked to an increased risk of DDE (OR: 1.37; 95%CI: 1.05, 1.80), while PFHpA showed a protective effect (OR: 0.72; 95%CI: 0.54, 0.97). No significant associations were observed between individual PFAS compounds and dental caries outcomes. Additionally, the study found a lack of significant associations between PFAS mixtures and the prevalence of DDE or dental caries, as well as the absence of any marked effects on DDE tooth count or dmft.</div></div><div><h3>Conclusion</h3><div>Although no overall association was observed between PFAS mixtures and oral health outcomes, certain short-chain PFAS compounds, such as PFBS and PFHpA, demonstrated distinct effects on enamel defects. Further research is warranted to clarify the biological mechanisms underlying these associations and to examine the role of PFAS exposure in other populations.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"198 ","pages":"Article 109411"},"PeriodicalIF":10.3000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environment International","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016041202500162X","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with potential health risks. While the association between PFAS and dental health is under-researched, this study aims to address this gap by investigating prenatal PFAS exposure in relation to Developmental Defects of Enamel (DDE) and dental caries in children.

Methods

This study included 1,136 children from the Shanghai Birth Cohort, with maternal blood samples collected during early pregnancy to measure concentrations of 10 PFAS compounds. Oral health outcomes, assessed when the children were 4 years old, included the prevalence of DDE and dental caries, as well as DDE tooth count and the decayed, missing, and filled teeth (dmft) index. Logistic regression and zero-inflated negative binomial regression were used to examine associations between individual PFAS compounds and oral health outcomes. Restricted Cubic Splines (RCS) were used to explore potential nonlinear associations. Additionally, Bayesian Kernel Machine Regression (BKMR), Weighted Quantile Sum (WQS), and Quantile G-Computation (QGC) were employed to assess the joint effects of PFAS mixtures on the outcomes.

Results

Individual PFAS compounds, particularly perfluorobutane sulfonate (PFBS) and perfluoroheptanoic acid (PFHpA), exhibited heterogeneous associations with DDE prevalence. PFBS was linked to an increased risk of DDE (OR: 1.37; 95%CI: 1.05, 1.80), while PFHpA showed a protective effect (OR: 0.72; 95%CI: 0.54, 0.97). No significant associations were observed between individual PFAS compounds and dental caries outcomes. Additionally, the study found a lack of significant associations between PFAS mixtures and the prevalence of DDE or dental caries, as well as the absence of any marked effects on DDE tooth count or dmft.

Conclusion

Although no overall association was observed between PFAS mixtures and oral health outcomes, certain short-chain PFAS compounds, such as PFBS and PFHpA, demonstrated distinct effects on enamel defects. Further research is warranted to clarify the biological mechanisms underlying these associations and to examine the role of PFAS exposure in other populations.

Abstract Image

查看原文本刊更多论文

4 岁儿童产前接触全氟烷基和多氟烷基物质及其与牙釉质发育缺陷（DDE）和龋齿的关系：来自上海出生队列的研究结果

全氟和多氟烷基物质（PFAS）是具有潜在健康风险的持久性环境污染物。虽然PFAS与牙齿健康之间的关系尚未得到充分研究，但本研究旨在通过调查产前PFAS暴露与儿童牙釉质发育缺陷（DDE）和龋齿的关系来解决这一空白。方法本研究包括来自上海出生队列的1136名儿童，在妊娠早期收集母亲血液样本，测量10种PFAS化合物的浓度。当儿童4岁 岁时，评估口腔健康结果，包括DDE和龋齿的患病率，DDE牙齿计数和蛀牙、缺牙和补牙（dmft）指数。使用逻辑回归和零膨胀负二项回归来检查单个PFAS化合物与口腔健康结果之间的关联。限制三次样条（RCS）用于探索潜在的非线性关联。此外，采用贝叶斯核机回归（BKMR）、加权分位数和（WQS）和分位数g计算（QGC）来评估PFAS混合物对结果的联合影响。结果单个PFAS化合物，特别是全氟丁烷磺酸（PFBS）和全氟庚酸（PFHpA），与DDE患病率表现出异质性关联。PFBS与DDE风险增加有关(OR: 1.37；95%CI: 1.05, 1.80)，而PFHpA具有保护作用(OR: 0.72；95%ci: 0.54, 0.97)。没有观察到单个PFAS化合物与龋齿结局之间的显著关联。此外，该研究发现PFAS混合物与DDE或龋齿患病率之间缺乏显着关联，对DDE牙齿计数或dmft也没有任何显着影响。结论虽然PFAS混合物与口腔健康结果之间没有全面的关联，但某些短链PFAS化合物，如PFBS和PFHpA，对牙釉质缺损有明显的影响。需要进一步的研究来阐明这些关联背后的生物学机制，并检查PFAS暴露在其他人群中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.