Maternal exposure to per- and polyfluoroalkyl substances and epitope level antibody response to vaccines against measles and rubella in children from the Boston birth cohort

IF 10.3 1区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environment International Pub Date : 2025-04-01 DOI:10.1016/j.envint.2025.109433

Xiumei Hong , William R. Morgenlander , Kari Nadeau , Guoying Wang , Pamela A. Frischmeyer-Guerrerio , Colleen Pearson , William G. Adams , Hongkai Ji , H. Benjamin Larman , Xiaobin Wang

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引用次数: 0

Abstract

Background

Previous studies suggest that per- and polyfluoroalkyl substances (PFAS) may act as immune suppressants. However, research about the impact of PFAS exposure on antibody responses to the measles, mumps, rubella (MMR) vaccine is limited and inconsistent.

Methods

This report includes 748 mother–child pairs from the Boston Birth Cohort, with 8 PFAS compounds measured in maternal plasma shortly after delivery. IgG reactivities to measles and rubella were profiled in cord blood and venous blood plasma during early childhood, using Phage ImmunoPrecipitation Sequencing. Linear regression models were applied to assess the relationships between log2-transformed PFAS and IgG reactivities as measured by Viral Aggregate Reactivity score (VARscore, with inverse normal transformation) for measles and rubella. Quantile g-computation was applied to evaluate the PFAS mixture – VARscore associations.

Results

The detection rate for 8 PFAS compounds ranged from 90 % to 100 % in maternal plasma. Maternal PFAS burden score (P = 0.01), but not individual PFAS compounds, was associated with lower VARscore for measles in cord blood. In 348 children after receiving the MMR vaccine, three maternal PFAS compounds (Me-PFOSA-AcOH, PFHpS and PFHxS) were significantly associated with lower measles VARscore (P < 0.05). Me-PFOSA-AcOH and PFHxS were significantly associated with higher risk of having low reactivity to measles defined as VARscore < 25th percentile. PFAS mixture analysis revealed a significant inverse association between quantile of the PFAS mixture and measles VARscore (P = 0.025) in children after vaccination, with PFHxS as an important contributor to this association. These inverse associations were more pronounced in Black children (compared to non-Black children) and in preterm children (compared to term children). In comparison, no associations were found for rubella VARscore.

Conclusions

This prospective birth cohort study provides suggestive evidence that maternal PFAS exposure is associated with a reduced immune response to the measles vaccine, especially, among Black or preterm children.

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波士顿出生队列中母亲对多氟烷基和全氟烷基物质的暴露和对麻疹、腮腺炎和风疹疫苗的表位水平抗体反应

以往的研究表明，全氟烷基和多氟烷基物质（PFAS）可能具有免疫抑制剂的作用。然而，关于PFAS暴露对麻疹、腮腺炎、风疹（MMR）疫苗抗体反应影响的研究有限且不一致。方法本报告包括来自波士顿出生队列的748对母婴，在分娩后不久的母体血浆中测量了8种PFAS化合物。应用噬菌体免疫沉淀测序技术分析了儿童早期脐带血和静脉血中IgG对麻疹和风疹的反应。采用线性回归模型来评估log2转化的PFAS与IgG反应性之间的关系，通过病毒总反应性评分（VARscore，反向正态转换）来测量对MMR疫苗的反应。分位数g计算用于评估PFAS混合物与VARscore的关联。结果8种PFAS化合物在母体血浆中的检出率为90% % ~ 100% %。母体PFAS负担评分（P = 0.01）与脐带血麻疹VARscore降低相关，而与单个PFAS化合物无关。在348名接种MMR疫苗后的儿童中，三种母体PFAS化合物（Me-PFOSA-AcOH， PFHpS和PFHxS）与较低的麻疹VARscore显著相关（P <； 0.05）。Me-PFOSA-AcOH和PFHxS与麻疹低反应性的高风险显著相关，以VARscore <； 第25百分位定义。PFAS混合物分析显示，接种后儿童PFAS混合物分位数与麻疹VARscore呈显著负相关（P = 0.02），其中PFHxS是该关联的重要贡献者。这些反向关联在黑人儿童（与非黑人儿童相比）和早产儿（与足月儿童相比）中更为明显。相比之下，风疹VARscore没有发现关联。这项前瞻性出生队列研究提供了启发性证据，表明母体PFAS暴露与对麻疹疫苗的免疫反应降低有关，特别是在黑人或早产儿中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environment International 环境科学-环境科学

CiteScore

21.90

自引率

3.40%

发文量

734

审稿时长

2.8 months

期刊介绍： Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.