Epidemiological and clinical insights into enterovirus circulation in Europe, 2018 - 2023: a multi-center retrospective surveillance study.

IF 5 2区 医学 Q2 IMMUNOLOGY
Sten de Schrijver, Emiel Vanhulle, Anne Ingenbleek, Leonidas Alexakis, Caroline Klint Johannesen, Eeva K Broberg, Heli Harvala, Thea K Fischer, Kimberley S M Benschop
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引用次数: 0

Abstract

Background: Enteroviruses (EV) cause yearly outbreaks with severe infections, particularly in young children. This study investigates EV circulation, age-distribution, and clinical presentations in Europe from 2018-2023.

Methods: Aggregated data were requested from ECDC National Focal Points for Surveillance and European Non-Polio Enterovirus Network. Data included detection month, specimen type, age-group, and clinical presentation for the ten most commonly reported EV types per year.

Findings: Twenty-eight institutions from 16 countries reported 563,654 EV-tests during the study-period with 33,265 (5.9%) EV-positive. Forty-two types were identified (n=11,605 cases) with echovirus (E)30, coxsackievirus (CV)A6, EV-D68, E9, E11, CVB5, E18, CVB4, EV-A71, and E6 most frequently reported. E30 detection declined after 2018/2019, while CVA6, CVB5, E9, E11, and EV-D68 were prevalent both before and after the COVID-19 pandemic, and CVB4 and E18 were prevalent after the pandemic. Over the study period, a shift in seasons (summer to fall) and specimen positivity (feces to respiratory) was observed. Neurological signs predominated among EV-A71, CVB4, CVB5, E6, E9, E11, E18, and E30 (30-72%). CVB4, CVB5, E9, E11, and E18 were also frequently reported among neonates (18-32%). CVA6 was frequently associated with HFMD, and EV-D68 with respiratory infections. Paralysis was reported among 22 infections, associated with ten non-polio types.

Conclusion: This study emphasizes the widespread circulation and severe nature of EV infections in Europe, particularly among neonates, as well as the (re-)emergence of specific types post-pandemic. Our findings highlight the need for continuous EV-surveillance to monitor variation in circulation, age, and clinical presentations, including paralysis among non-polio EV infections.

2018 - 2023年欧洲肠病毒传播的流行病学和临床洞察:一项多中心回顾性监测研究
背景:肠病毒(EV)每年引起严重感染,特别是在幼儿中。本研究调查了2018-2023年欧洲的EV循环、年龄分布和临床表现。方法:从ECDC国家监测联络点和欧洲非脊髓灰质炎肠病毒网络索取汇总数据。数据包括每年10种最常见的EV类型的检测月份、标本类型、年龄组和临床表现。研究结果:在研究期间,来自16个国家的28个机构报告了563,654例ev检测,其中33,265例(5.9%)ev阳性。共鉴定出42种病毒(11,605例),其中以埃可病毒(E)30、柯萨奇病毒(CV)A6、EV-D68、E9、E11、CVB5、E18、CVB4、EV-A71和E6最常见。2018/2019年疫情后E30检出率下降,疫情前后CVA6、CVB5、E9、E11、EV-D68流行,疫情后CVB4、E18流行。在研究期间,观察到季节(夏季到秋季)和标本阳性(粪便到呼吸道)的变化。神经学症状在EV-A71、CVB4、CVB5、E6、E9、E11、E18和E30中占主导地位(30-72%)。新生儿中也经常报告CVB4、CVB5、E9、E11和E18(18-32%)。CVA6常与手足口病相关,EV-D68常与呼吸道感染相关。在22例感染中报告了瘫痪,与10种非脊髓灰质炎类型有关。结论:这项研究强调了欧洲EV感染的广泛传播和严重性,特别是在新生儿中,以及大流行后特定类型的(重新)出现。我们的研究结果强调需要持续监测EV,以监测循环、年龄和临床表现的变化,包括非脊髓灰质炎EV感染中的瘫痪。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Infectious Diseases
Journal of Infectious Diseases 医学-传染病学
CiteScore
13.50
自引率
3.10%
发文量
449
审稿时长
2-4 weeks
期刊介绍: Published continuously since 1904, The Journal of Infectious Diseases (JID) is the premier global journal for original research on infectious diseases. The editors welcome Major Articles and Brief Reports describing research results on microbiology, immunology, epidemiology, and related disciplines, on the pathogenesis, diagnosis, and treatment of infectious diseases; on the microbes that cause them; and on disorders of host immune responses. JID is an official publication of the Infectious Diseases Society of America.
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