A global collaboration for systematic analysis of broad-ranging antibodies against the SARS-CoV-2 spike protein.

IF 7.5 1区生物学 Q1 CELL BIOLOGY

Cell reports Pub Date : 2025-04-02 DOI:10.1016/j.celrep.2025.115499

Sharon L Schendel, Xiaoying Yu, Peter J Halfmann, Jarjapu Mahita, Brendan Ha, Kathryn M Hastie, Haoyang Li, Daniel Bedinger, Camille Troup, Kan Li, Natalia Kuzmina, Jordi B Torrelles, Jennifer E Munt, Melissa Maddocks, Mary Osei-Twum, Heather M Callaway, Stephen Reece, Anne Palser, Paul Kellam, S Moses Dennison, Richard H C Huntwork, Gillian Q Horn, Milite Abraha, Elizabeth Feeney, Luis Martinez-Sobrido, Paula A Pino, Amberlee Hicks, Chengjin Ye, Jun-Gyu Park, Billie Maingot, Sivakumar Periasamy, Michael Mallory, Trevor Scobey, Marie-Noelle Lepage, Natalie St-Amant, Sarwat Khan, Anaïs Gambiez, Ralph S Baric, Alexander Bukreyev, Luc Gagnon, Timothy Germann, Yoshihiro Kawaoka, Georgia D Tomaras, Bjoern Peters, Erica Ollmann Saphire

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引用次数: 0

Abstract

The Coronavirus Immunotherapeutic Consortium (CoVIC) conducted side-by-side comparisons of over 400 anti-SARS-CoV-2 spike therapeutic antibody candidates contributed by large and small companies as well as academic groups on multiple continents. Nine reference labs analyzed antibody features, including in vivo protection in a mouse model of infection, spike protein affinity, high-resolution epitope binning, ACE-2 binding blockage, structures, and neutralization of pseudovirus and authentic virus infection, to build a publicly accessible dataset in the database CoVIC-DB. High-throughput, high-resolution binning of CoVIC antibodies defines a broad and predictive landscape of antibody epitopes on the SARS-CoV-2 spike protein and identifies features associated with durable potency against multiple SARS-CoV-2 variants of concern and high in vivo efficacy. Results of the CoVIC studies provide a guide for selecting effective and durable antibody therapeutics and for immunogen design as well as providing a framework for rapid response to future viral disease outbreaks.

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来源期刊

Cell reports CELL BIOLOGY-

CiteScore

13.80

自引率

1.10%

发文量

1305

审稿时长

77 days

期刊介绍： Cell Reports publishes high-quality research across the life sciences and focuses on new biological insight as its primary criterion for publication. The journal offers three primary article types: Reports, which are shorter single-point articles, research articles, which are longer and provide deeper mechanistic insights, and resources, which highlight significant technical advances or major informational datasets that contribute to biological advances. Reviews covering recent literature in emerging and active fields are also accepted. The Cell Reports Portfolio includes gold open-access journals that cover life, medical, and physical sciences, and its mission is to make cutting-edge research and methodologies available to a wide readership. The journal's professional in-house editors work closely with authors, reviewers, and the scientific advisory board, which consists of current and future leaders in their respective fields. The advisory board guides the scope, content, and quality of the journal, but editorial decisions are independently made by the in-house scientific editors of Cell Reports.