Strong bacterial cellulose/poly(vinyl alcohol)/glycerol tubes with bioactive poly(vinyl alcohol)/silk microfibers hydrogel sheaths for esophageal grafts

IF 4.9 2区工程技术 Q1 MATERIALS SCIENCE, PAPER & WOOD

Cellulose Pub Date : 2025-02-21 DOI:10.1007/s10570-025-06428-8

Ke Wang, Jin Yan, Raj Shankar Hazra, Qian Ma, Long Jiang, Yuanming Zhang, Hongtao Zhou, Guangting Han, Shudong Wang

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Abstract

Tubular esophageal grafts have been widely studied for their potential in replacing tissue damaged by esophageal cancer. However, developing readily available grafts for clinical use remains challenging due to high rates of esophageal leakage and limited biocompatibility. Herein, bilayer bacterial cellulose (BC)/poly(vinyl alcohol) (PVA)/glycerol (Gly)-PVA/silk microfiber (SMF) tubes were developed, featuring an inner BC/PVA/Gly layer and an outer PVA/SMF hydrogel sheath. The tubes were fabricated through a combination of rolling and freeze-thawing, creating a strong inner BC/PVA/Gly layer and a bioactive outer PVA/SMF hydrogel layer. The effects of the inner layer’s thickness and SMF content on the morphology, microstructure, thermal stability, mechanical properties, suture retention strength, and burst pressure strength of the bilayer tubes were examined. The inner BC/PVA/Gly tubes exhibited a compact structure, while the outer PVA/SMF sheaths had a porous architecture. The mechanical properties, suture retention strength, and burst pressure strength of the bilayer tubes were much greater than that of the native esophagus. Hemocompatibility and cytocompatibility testing confirmed the excellent blood compatibility and strong biocompatibility of these new bilayer tubes, largely attributed to the SMF content. These characteristics highlight the potential of bilayer BC/PVA/Gly-PVA/SMF tubes as promising candidates for esophageal graft applications.

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来源期刊

Cellulose 工程技术-材料科学：纺织

CiteScore

10.10

自引率

10.50%

发文量

580

审稿时长

3-8 weeks

期刊介绍： Cellulose is an international journal devoted to the dissemination of research and scientific and technological progress in the field of cellulose and related naturally occurring polymers. The journal is concerned with the pure and applied science of cellulose and related materials, and also with the development of relevant new technologies. This includes the chemistry, biochemistry, physics and materials science of cellulose and its sources, including wood and other biomass resources, and their derivatives. Coverage extends to the conversion of these polymers and resources into manufactured goods, such as pulp, paper, textiles, and manufactured as well natural fibers, and to the chemistry of materials used in their processing. Cellulose publishes review articles, research papers, and technical notes.