Enhanced drug delivery using surface-roughened MgO@Silica nanoparticles loaded with doxorubicin

IF 4.8 3区材料科学 Q1 CHEMISTRY, APPLIED

Microporous and Mesoporous Materials Pub Date : 2025-04-03 DOI:10.1016/j.micromeso.2025.113624

Manoj Kumar Sharma , Nidhi Aggarwal , Ravi Kumar , Jiban Jyoti Panda , Chengzhong Yu , Ashok K. Ganguli

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引用次数: 0

Abstract

Nanoparticle based drug carriers have attracted considerable interest in drug delivery applications. However, their low drug loading efficiency of certain chemotherapeutic agents, insufficient cellular uptake, and limited in-vitro efficacy remain a significant challenge. In this study, we have synthesized and characterized MgO@silica core-shell nanoparticles with distinct surface morphologies: MgO@silica-smooth(S) and MgO@silica-rough(R). The rough-surfaced MgO@silica-R exhibited a significantly higher surface area and drug encapsulation efficiency (∼97 %) for the anticancer drug doxorubicin (Dox), compared to the smooth MgO@silica-S counterpart (∼37 %). The rough morphology of MgO@silica-R resulted in sustained drug release and a 2.5-fold increase in cellular uptake inside C6 glioma cells as compared to free Dox. Dox-loaded MgO@silica-R showed superior anticancer efficacy, inducing ∼90 % cell death, surpassing both MgO@silica-S and free Dox. These findings underscore the potential of MgO@silica-based nanoparticles, particularly those with rough surface properties, as effective carriers for targeted drug delivery and cancer treatment.

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使用表面粗糙的MgO@Silica纳米颗粒装载阿霉素增强药物递送

基于纳米颗粒的药物载体在药物递送应用中引起了相当大的兴趣。然而，某些化疗药物的载药效率低，细胞摄取不足，体外疗效有限仍然是一个重大挑战。在这项研究中，我们合成并表征了MgO@silica核壳纳米颗粒，它们具有不同的表面形态：MgO@silica-smooth(S)和MgO@silica-rough(R)。与光滑的MgO@silica-S对应物（~ 37%）相比，粗糙表面的MgO@silica-R对抗癌药物阿霉素（Dox）具有显着更高的表面积和药物包封效率（~ 97%）。MgO@silica-R的粗糙形态导致药物持续释放，与游离Dox相比，C6胶质瘤细胞内的细胞摄取增加2.5倍。负载Dox的MgO@silica-R表现出优越的抗癌功效，诱导约90%的细胞死亡，超过MgO@silica-S和游离Dox。这些发现强调了MgO@silica-based纳米颗粒的潜力，特别是那些具有粗糙表面特性的纳米颗粒，作为靶向药物输送和癌症治疗的有效载体。

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来源期刊

Microporous and Mesoporous Materials 化学-材料科学：综合

CiteScore

10.70

自引率

5.80%

发文量

649

审稿时长

26 days

期刊介绍： Microporous and Mesoporous Materials covers novel and significant aspects of porous solids classified as either microporous (pore size up to 2 nm) or mesoporous (pore size 2 to 50 nm). The porosity should have a specific impact on the material properties or application. Typical examples are zeolites and zeolite-like materials, pillared materials, clathrasils and clathrates, carbon molecular sieves, ordered mesoporous materials, organic/inorganic porous hybrid materials, or porous metal oxides. Both natural and synthetic porous materials are within the scope of the journal. Topics which are particularly of interest include: All aspects of natural microporous and mesoporous solids The synthesis of crystalline or amorphous porous materials The physico-chemical characterization of microporous and mesoporous solids, especially spectroscopic and microscopic The modification of microporous and mesoporous solids, for example by ion exchange or solid-state reactions All topics related to diffusion of mobile species in the pores of microporous and mesoporous materials Adsorption (and other separation techniques) using microporous or mesoporous adsorbents Catalysis by microporous and mesoporous materials Host/guest interactions Theoretical chemistry and modelling of host/guest interactions All topics related to the application of microporous and mesoporous materials in industrial catalysis, separation technology, environmental protection, electrochemistry, membranes, sensors, optical devices, etc.