Construction of nomogram prognostic model for gastric signet ring cell carcinoma: Signet ring cell proportion influencing prognosis

IF 3.5 2区医学 Q2 ONCOLOGY

Ejso Pub Date : 2025-04-02 DOI:10.1016/j.ejso.2025.110012

Wannian Sui , Peifeng Chen , Zhangming Chen, Wenxiu Han

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引用次数: 0

Abstract

Background

Signet ring cell (SRC) carcinoma significantly impacts the prognosis of gastric cancer (GC) patients, yet the influence of SRC proportion is often overlooked. This study aims to clarify the relationship between SRC proportion and prognosis and to construct a prognostic prediction model for gastric cancer patients with SRC components (GSRCC).

Methods

Clinical data from 628 GSRCC patients who underwent gastrectomy at the First Affiliated Hospital of Anhui Medical University from November 2011 to December 2018 were collected. Patients were randomly divided into a training set (442 patients) and a validation set (186 patients). Prognostic risk factors were identified in the training set, and a nomogram prediction model was established. The internal and external validation were conducted on the training and validation sets.

Results

The SRC proportion (hazard ratio [HR]: 9.569, P < 0.001), depth of invasion (HR: 6.838, P = 0.001), tumor size (HR: 1.573, P = 0.044), and N stage (HR: 6.511, P < 0.001) were independent prognostic factors for GSRCC. The nomogram showed excellent performance in predicting 1-year, 3-year, and 5-year overall survival (OS) with AUC values of 0.819, 0.832, and 0.874 in the training set, and of 0.815, 0.847, and 0.876 in the validation set, respectively. Calibration curves indicated good agreement between predicted and actual survival rates.

Conclusions

The SRC proportion influences the prognosis of GSRCC patients. The establishment of the prognostic prediction model will provide assistance for clinical decision-making and prognosis assessment.

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胃标志环细胞癌预后提名图模型的构建：影响预后的标志环细胞比例

背景肉桂环细胞癌（SRC）对胃癌（GC）患者的预后有显著影响，但SRC比例的影响往往被忽视。本研究旨在阐明SRC比例与预后的关系，并构建SRC成分胃癌患者（GSRCC）的预后预测模型。方法收集2011年11月至2018年12月在安徽医科大学第一附属医院接受胃切除术的628例GSRCC患者的临床数据。患者被随机分为训练集（442例）和验证集（186例）。在训练集中确定了预后风险因素，并建立了提名图预测模型。结果SRC比例（危险比[HR]：9.569，P <0.001）、浸润深度（HR：6.838，P = 0.001）、肿瘤大小（HR：1.573，P = 0.044）和N分期（HR：6.511，P <0.001）是GSRCC的独立预后因素。提名图在预测1年、3年和5年总生存期（OS）方面表现出色，训练集的AUC值分别为0.819、0.832和0.874，验证集的AUC值分别为0.815、0.847和0.876。结论 SRC比例影响GSRCC患者的预后。预后预测模型的建立将为临床决策和预后评估提供帮助。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ejso 医学-外科

CiteScore

6.40

自引率

2.60%

发文量

1148

审稿时长

41 days

期刊介绍： JSO - European Journal of Surgical Oncology ("the Journal of Cancer Surgery") is the Official Journal of the European Society of Surgical Oncology and BASO ~ the Association for Cancer Surgery. The EJSO aims to advance surgical oncology research and practice through the publication of original research articles, review articles, editorials, debates and correspondence.