Effect of Transcatheter Edge-to-Edge Repair on Left Ventricular Flow Features.

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Engineering and Technology Pub Date : 2025-04-03 DOI:10.1007/s13239-025-00781-2

Xinyi He, Shuyi Feng, Fan Wu, Hongping Wang, Shizhao Wang, Xiangbin Pan

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引用次数: 0

Abstract

Purpose: This study aims to investigate the effects of transcatheter edge-to-edge repair (TEER) on left ventricular hemodynamics and its potential implications for patient health.

Methods: An in vitro experimental platform was designed to replicate the anatomical and functional characteristics of the left ventricle (LV). This platform integrates native porcine mitral and aortic valves with a patient-specific 3D-printed silicone LV. The LV hemodynamics after TEER is assessed using echocardiography and particle image velocimetry, focusing on critical indices such as vorticity, Reynolds shear stress (RSS), viscous shear stress (VSS), and energy dissipation rate (ε).

Results: TEER effectively reduces the degree of mitral regurgitation (MR); however, it significantly increases RSS, VSS, and ε due to the formation of numerous small-scale vortices in the LV.

Conclusion: These hemodynamic changes may lead to adverse left ventricular remodeling, red blood cell damage, and reduced cardiac pumping efficiency, which have to be taken into consideration to optimize the TEER procedure and improve patient outcomes.

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经导管边缘对边缘修复对左心室血流特征的影响。

目的：本研究旨在探讨经导管边缘到边缘修复（TEER）对左心室血流动力学的影响及其对患者健康的潜在影响。方法：设计体外实验平台，复制左心室的解剖和功能特征。该平台将本地猪二尖瓣和主动脉瓣与患者特定的3d打印硅胶LV集成在一起。采用超声心动图和颗粒图像测速法评估TEER后左室血流动力学，重点关注涡度、雷诺剪切应力（RSS）、粘性剪切应力（VSS）和能量耗散率（ε）等关键指标。结果：TEER能有效降低二尖瓣反流程度；然而，由于低压中大量小尺度涡的形成，它显著增加了RSS、VSS和ε。结论：这些血流动力学变化可能导致不良的左心室重构、红细胞损伤和心脏泵血效率降低，优化TEER手术和改善患者预后时应予以考虑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Engineering and Technology Engineering-Biomedical Engineering

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Cardiovascular Engineering and Technology is a journal publishing the spectrum of basic to translational research in all aspects of cardiovascular physiology and medical treatment. It is the forum for academic and industrial investigators to disseminate research that utilizes engineering principles and methods to advance fundamental knowledge and technological solutions related to the cardiovascular system. Manuscripts spanning from subcellular to systems level topics are invited, including but not limited to implantable medical devices, hemodynamics and tissue biomechanics, functional imaging, surgical devices, electrophysiology, tissue engineering and regenerative medicine, diagnostic instruments, transport and delivery of biologics, and sensors. In addition to manuscripts describing the original publication of research, manuscripts reviewing developments in these topics or their state-of-art are also invited.