Three's company: Membrane waltz among organelles

IF 3.4 2区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Valentin Guyard, Francesca Giordano
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引用次数: 0

Abstract

The study of membrane contact sites (MCS) has profoundly transformed our understanding of inter-organelle communication. These sites, where the membranes of two organelles are closely apposed, facilitate the transfer of small molecules such as lipids and ions. They are especially crucial for the maintenance of the structure and function of organelles like mitochondria and lipid droplets, which are largely excluded from vesicular trafficking. The significant advancements in imaging techniques, and molecular and cell biology research have shown that MCS are more complex than what originally thought and can involve more than two organelles. This has revealed the intricate nature and critical importance of these subcellular connections.
Here, we provide an overview of newly described three-way inter-organelles associations, and the proteins involved in these MCS. We highlight the roles these contacts play in key cellular processes such as lipid droplet biogenesis and mitochondrial division. Additionally, we discuss the latest advances in super-resolution imaging that enable the study of these complex three-way interactions. Ongoing research, driven by technological innovations, promises to uncover further insights into their roles in fundamental cellular processes and their implications for health and disease.
三人行细胞器之间的膜华尔兹
膜接触位点(MCS)的研究深刻地改变了我们对细胞器间通讯的理解。这些位置是两个细胞器的膜紧密相连的地方,促进小分子(如脂质和离子)的转移。它们对于维持线粒体和脂滴等细胞器的结构和功能尤其重要,这些细胞器在很大程度上被排除在囊泡运输之外。成像技术、分子和细胞生物学研究的重大进展表明,MCS比最初想象的要复杂得多,可能涉及两个以上的细胞器。这揭示了这些亚细胞连接的复杂性质和关键重要性。在这里,我们提供了新描述的三种细胞器间结合的概述,以及这些MCS中涉及的蛋白质。我们强调了这些接触在关键细胞过程中所起的作用,如脂滴生物发生和线粒体分裂。此外,我们讨论了超分辨率成像的最新进展,使这些复杂的三方相互作用的研究成为可能。在技术创新的推动下,正在进行的研究有望进一步揭示它们在基本细胞过程中的作用及其对健康和疾病的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biochimica et Biophysica Acta-Bioenergetics
Biochimica et Biophysica Acta-Bioenergetics 生物-生化与分子生物学
CiteScore
9.50
自引率
7.00%
发文量
363
审稿时长
92 days
期刊介绍: BBA Bioenergetics covers the area of biological membranes involved in energy transfer and conversion. In particular, it focuses on the structures obtained by X-ray crystallography and other approaches, and molecular mechanisms of the components of photosynthesis, mitochondrial and bacterial respiration, oxidative phosphorylation, motility and transport. It spans applications of structural biology, molecular modeling, spectroscopy and biophysics in these systems, through bioenergetic aspects of mitochondrial biology including biomedicine aspects of energy metabolism in mitochondrial disorders, neurodegenerative diseases like Parkinson''s and Alzheimer''s, aging, diabetes and even cancer.
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