Genetic evidence links hyperthyroidism to knee osteoarthritis.

IF 2.4 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Hormones-International Journal of Endocrinology and Metabolism Pub Date : 2025-04-04 DOI:10.1007/s42000-025-00648-0

Tianli Xu, Limin Shen, Xiaojun Cao, Jincheng Song, Mengjie Tang, Chaoyan Yue

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引用次数: 0

Abstract

Purpose: The causal relationship between hyperthyroidism and knee osteoarthritis (KOA) remains to date unknown. We aimed to examine the potential causal relationship between hyperthyroidism status and the risk of developing KOA via a bidirectional two-sample Mendelian randomization (MR) approach.

Methods: Single-nucleotide polymorphism (SNP) data related to hyperthyroidism and KOA were obtained from a genome-wide association study (GWAS) in Europe. KOA was used as the outcome variable and hyperthyroidism was used as the exposure factor. The inverse-variance weighted (IVW) method served as the primary analytic tool and heterogeneity and pleiotropy were evaluated via sensitivity analysis.

Results: The IVW method indicated that hyperthyroidism status has a causative influence on the risk of developing KOA [OR, 1.046; 95% confidence interval (CI), 1.013-1.080; P = 0.006]. No significant reverse causality was detected. Sensitivity analyses validated the robustness of these findings.

Conclusions: Hyperthyroidism status can causally increase the risk of developing KOA. This result indicated that the risk of developing KOA may be decreased by controlling hyperthyroidism.

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遗传证据表明甲亢与膝骨关节炎有关。

目的：甲状腺功能亢进与膝骨关节炎（KOA）之间的因果关系尚不清楚。我们旨在通过双向双样本孟德尔随机化（MR）方法研究甲状腺功能亢进状态与发生KOA风险之间的潜在因果关系。方法：从欧洲的全基因组关联研究（GWAS）中获得与甲亢和KOA相关的单核苷酸多态性（SNP）数据。KOA作为结局变量，甲状腺功能亢进作为暴露因素。以反方差加权法（IVW）为主要分析工具，通过敏感性分析评价异质性和多效性。结果：IVW方法提示甲亢状态对发生KOA的风险有致病影响[OR， 1.046；95%置信区间（CI）， 1.013-1.080；p = 0.006]。未发现显著的反向因果关系。敏感性分析验证了这些发现的稳健性。结论：甲亢状态可增加KOA发生的风险。提示控制甲状腺功能亢进可降低KOA的发生风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormones-International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

5.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hormones-International Journal of Endocrinology and Metabolism is an international journal published quarterly with an international editorial board aiming at providing a forum covering all fields of endocrinology and metabolic disorders such as disruption of glucose homeostasis (diabetes mellitus), impaired homeostasis of plasma lipids (dyslipidemia), the disorder of bone metabolism (osteoporosis), disturbances of endocrine function and reproductive capacity of women and men. Hormones-International Journal of Endocrinology and Metabolism particularly encourages clinical, translational and basic science submissions in the areas of endocrine cancers, nutrition, obesity and metabolic disorders, quality of life of endocrine diseases, epidemiology of endocrine and metabolic disorders.