A noncanonical scaffold in steroidal metabolism.

Abstract

A recent study by Boccia et al. identified GAME15, a cellulose synthase-like protein that is essential for steroidal saponin and glycoalkaloid biosynthesis in Solanum species. GAME15 functions as a scaffold, interacting with key enzymes involved in the early steps of biosynthesis, enabling metabolic flux from cholesterol to steroidal defense compounds.