Critical illness and sex hormones: response and impact of the hypothalamic-pituitary-gonadal axis.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Therapeutic Advances in Endocrinology and Metabolism Pub Date : 2025-04-02 eCollection Date: 2025-01-01 DOI:10.1177/20420188251328192

Yicheng Ma, Xiude Fan, Junming Han, Yiping Cheng, Jiajun Zhao, Wei Fang, Ling Gao

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引用次数: 0

Abstract

Understanding the hypothalamic-pituitary-gonadal (HPG) axis is essential for grasping human responses under extreme physiological and pathological conditions. The HPG axis regulates reproductive and gonadal hormone activities and significantly impacts the body's response to acute and chronic illnesses. This review explores the fundamental functions of the HPG axis, modifications under critical conditions, and impacts on disease progression and treatment outcomes. In addition, it examines interactions between sex hormones and biomolecules like cytokines and gastrointestinal microorganisms, highlighting their roles in immune response regulation. Clinically, this knowledge can enhance patient prognoses. The review aims to provide a comprehensive framework, based on existing research, for understanding and applying the functions of the HPG axis in managing critical diseases, thereby broadening clinical applications and guiding future research.

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危重疾病与性激素：下丘脑-垂体-性腺轴的反应和影响。

了解下丘脑-垂体-性腺（HPG）轴对于掌握人类在极端生理和病理条件下的反应是必不可少的。HPG轴调节生殖和性腺激素活动，并显著影响人体对急性和慢性疾病的反应。这篇综述探讨了HPG轴的基本功能，在关键条件下的改变，以及对疾病进展和治疗结果的影响。此外，它还研究了性激素与细胞因子和胃肠道微生物等生物分子之间的相互作用，突出了它们在免疫反应调节中的作用。在临床上，这些知识可以提高患者的预后。本文旨在基于现有研究，为理解和应用HPG轴在危重疾病管理中的功能提供一个全面的框架，从而拓宽临床应用，指导未来的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Advances in Endocrinology and Metabolism Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

7.70

自引率

2.60%

发文量

审稿时长

8 weeks

期刊介绍： Therapeutic Advances in Endocrinology and Metabolism delivers the highest quality peer-reviewed articles, reviews, and scholarly comment on pioneering efforts and innovative studies across all areas of endocrinology and metabolism.