Comparative efficacy of exercise, nutrition, and combined exercise and nutritional interventions in older adults with sarcopenic obesity: a protocol for systematic review and network meta-analysis.
Youwen Gong, Yongqiang Yang, Xueqing Zhang, Li Tong
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引用次数: 0
Abstract
Background: Sarcopenic obesity (SO) in older adults is associated with certain adverse outcomes, including falls, fractures, and disability, all of which affect patient quality of life, represent an economic burden, and potentially enhance the risk of death. Although a number studies have examined the effects of exercise, nutrition, and combined exercise and nutritional interventions on older adults with SO, the optimal therapeutic approach has yet to be sufficiently established. In this systematic review and network meta-analysis (NMA) protocol for SO in older adults, we aim to compare the combined effects of exercise and nutrition with those of exercise or nutritional interventions alone on the body composition and physical performance of older adults with SO.
Methods: The PubMed, Web of Science, Embase, OVID, CINAHL, CNKI, Wanfang Data, and VIP databases will be used to systematically search for randomized controlled trials published from the time of database inception to December 2024. Outcomes will include body composition and physical performance, and data will be extracted independently by two researchers. In cases of disagreement, a consensus will be reached by consulting a third researcher. The Cochrane risk-of-bias tool will be used to assess randomized controlled trials, and data analysis will be performed using Stata 15.0 and R software, based on homogeneity, sensitivity, transitivity, consistency, and publication bias tests.
Discussion: By comprehensively assessing the relative efficacies of exercise, nutrition, and combined interventions in older adults with SO, we aim in this systematic review and NMA to fill an important gap in the existing literature. These findings will provide a reference for healthcare providers and policymakers and facilitate the development of evidence-based guidelines that will contribute to optimizing SO management and gaining more favorable outcomes for this vulnerable population.
背景：老年人肌肉减少性肥胖（SO）与某些不良结局相关，包括跌倒、骨折和残疾，所有这些都会影响患者的生活质量，带来经济负担，并可能增加死亡风险。尽管许多研究已经检验了运动、营养以及运动和营养相结合的干预措施对老年SO患者的影响，但最佳治疗方法尚未充分确立。在这项针对老年人SO的系统回顾和网络荟萃分析（NMA）方案中，我们旨在比较运动和营养联合干预与单独运动或营养干预对老年人SO的身体成分和身体表现的影响。方法：系统检索PubMed、Web of Science、Embase、OVID、CINAHL、CNKI、万方数据、VIP等数据库，检索自建库至2024年12月已发表的随机对照试验。结果将包括身体成分和身体表现，数据将由两名研究人员独立提取。如果有分歧，将通过咨询第三位研究员来达成共识。使用Cochrane风险偏倚工具评估随机对照试验，使用Stata 15.0和R软件进行数据分析，基于同质性、敏感性、传递性、一致性和发表偏倚检验。讨论：通过全面评估运动、营养和联合干预对老年SO患者的相对疗效，我们的目标是在这一系统综述和NMA中填补现有文献中的一个重要空白。这些发现将为医疗保健提供者和政策制定者提供参考，并促进基于证据的指南的发展，这将有助于优化SO管理，并为这一弱势群体获得更有利的结果。系统评价注册：CRD42024504706。
期刊介绍：
Systematic Reviews encompasses all aspects of the design, conduct and reporting of systematic reviews. The journal publishes high quality systematic review products including systematic review protocols, systematic reviews related to a very broad definition of health, rapid reviews, updates of already completed systematic reviews, and methods research related to the science of systematic reviews, such as decision modelling. At this time Systematic Reviews does not accept reviews of in vitro studies. The journal also aims to ensure that the results of all well-conducted systematic reviews are published, regardless of their outcome.
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